tbx21基因启动子rsnp功能鉴定及其与th1th2分化关系的研究-functional identification of tb x21 gene promoter rsnp and its relationship with th1th2 differentiation.docxVIP

associated with chronic HBV infection, autoimmune hepatitis and systemic lupus erythematosus.These autoimmune diseases may be resulted from a molecular genetic mechanism related with the absence of immune tolerance or a suppressed immune response .Genetic association studies can not explain whether TBX21 gene function is directly affected by the T-1993C polymorphism, or the other which has a linkage disequilibrium relationship with the T-1993C polymorphism. To better understand the regulatory mechanism of T-bet expression and its associated host susceptibility of autoimmune diseases, allergic