不同宫颈组织中rhoa nm23-h1的表达及临床意义-expression and clinical significance of rhoa nm23 - h1 in different cervical tissues.docxVIP

在宫颈鳞癌组中患者的阳性表达率为 54.55%（36/66），两组之间相 比较，差异有统计学的意义（2＝9.408，P＝0.002）。4.在宫颈鳞癌组患者中，淋巴结没有转移的患者组织中 nm23-H1 的阳性表达率（62%，31/50)远远高于有淋巴结转移的患者的阳 性表达率（25%，4/16)，两组之间的差异有统计学意义（2＝6.662，P＝0.010），而 nm23-H1 的阳性表达率与其它的临床病理学指标如 患者的年龄、FIGO 临床分期、病理分级、间质浸润的深度没有关系， 差异均没有统计学意义（P＞0.05）。5．RhoA 和 nm23-H1 在宫颈鳞癌组织中的表达无相关性（rs＝–0.235，P＝0.057）。结论：1.RhoA 在正常宫颈组织、CIN 还有宫颈鳞癌组织中的 阳性表达率呈逐渐升高的趋势，nm23-H1 在正常宫颈组织、CIN 及 宫颈鳞癌组织中的阳性表达率呈逐渐降低趋势，说明两者与宫颈鳞 癌的发生发展有可能相关。2.在宫颈鳞癌组织中，RhoA 在 45 岁以下患者中的阳性表达率 高于 45 岁以上患者中的阳性表达率，随着病理分级的降低，RhoA 的阳性表达率呈依次升高的趋势，在有淋巴结转移患者中阳性表达 率高于没有淋巴结转移的患者；nm23-H1 在没有淋巴结转移的患者 中的阳性表达率比有淋巴结转移的患者中的阳性表达率要高。3. RhoA 与 nm23-H1 在宫颈鳞癌中的表达没有相关性。 关键词：RhoA；nm23-H1；宫颈鳞癌；免疫组织化学The expression and clinical significance of RhoA and nm23-H1 in different cervical tissuesAbstractObjective To study the expression of RhoA and nm23-H1 in the normal cervical epithelium(NCE), cervical intraepithelial neoplasia(CIN) and squamous carcinomas of cervix(SCC), and analyzing their functions and relationships in the squamous carcinomas of cervix carcinogenesis and development mechanism.Methods:1.The biopsy paraffin embedded samples after surgical removal used in this study all were selected from the Affiliated Hospital of LuZhou Medical College ,Department of Pathology from May,2010 to November ,2011:66 cases of SCC,28 cases of CIN,10 cases of NCE. 66 cases of squamous carcinomas of cervix, more than 45 years of age have 26 cases,46 cases less than 45 years of age; International Federation ofGynecology and Obstetrics (FIGO) in 2009 in phases: Phase Ⅰ of 22cases, Phase Ⅱof 44 cases;16 cases with lymph node metastasis,50 caseswithout lymph node metastasis; pathologic grade: 16 cases of well- differentiated(G1),moderately differentiated(G2) 38 cases,12 cases of poorly differentiated;superficial myometrial infiltration of 20 cases,46 cases of deep myometrial and full-thickness infiltration.CIN group of specimens taken from the outpatient colposcopic cervical biopsy,or the patients who came to hospital to do the cer