Stem cells and a lot more…...pptVIP

The stem cell century Dr.Saranya Nandakumar Medical Director Asia CRYO CELL Pvt Ltd Chief sources of stem cells Other sources Almost all the organs in the body in small quantities Fat – one of the richest sources ( 150 ccs - 4 million cells) OEC – Olfactory Ensheathing Cells Teeth – Milk teeth and wisdom teeth Cord lining Amnion Why is this cell so special ? Plasticity or ability to differentiate Ability to divide continuously Immunological immaturity The Stem cell controversy The non controversial sources Bone Marrow Qty of harvest larger Engraftment faster GVHR 75% Contamination more Tedious collection Longer time to find donors HLA typing –5/6 or 6/6 Cord blood Harvest quantum less Engraftment takes longer GVHR 38% Less contamination Simple collection Donor search time –halved HLA match –3/6 or 4/6 Rate of Increase in Indian Population Per Year = 1,55,31,000 Per Month = 12,73,033 Per Day = 42,434 Per Hour = 1,768 Per Minute = 29 Types of cord blood banks Public banks Use not restricted. No remuneration collected Usage subject to availability Private banks For use of the family Facility paid for by the family Availability guaranteed Distribution of banks world-wide Around 100 of which 75 are public banks 40 in US, 30 in the UK, 20 in Asia and 10 in Australia Common Misconceptions The baby or siblings will never need the stem cells if my family doesnt have a history of cancer. Doctors would never treat the child with his or her own cord blood ?because it would contain the disease. “Cord blood collection takes important blood away from my baby” Studies on Viability Proceedings of the National Academy of Sciences, Broxmeyer and his co-author – study conclusions Human cord blood frozen in 1985 and 1986 was able to grow in laboratory cultures with the same vigour as fresh cord blood. Such cells frozen for a decade and a half can be used successfully to treat patient