[整理版]建立基因敲除小鼠颈动脉粥样硬化模型.pptVIP

Lipoprotein Lipase (LPL) Deficiency Increases Plasma Lipid Level and Enhances Neointima Formation After Carotid Artery Injury in apoE Knock-out Mice Candidate genes in lipoprotein metabolism Lipoprotein Lipase in the Arterial Wall Lipoprotein Lipase in the Arterial Wall Hypothesis neointima formation after carotid artery injury by FeCl3 for 8 weeks neointima formation after carotid artery injury by FeCl3 for 8 weeks Mean Intimal and Medial Cross-sectional Areas of EK and ELK Mice 8 Weeks after Injury lipid deposit after carotid artery injury by FeCl3 for 8 weeks lipid deposit after carotid artery injury by FeCl3 for 8 weeks lipid deposit after carotid artery injury by FeCl3 for 8 weeks lipid deposit after carotid artery injury by FeCl3 for 8 weeks Reference Mary Beth DeYoung, Clifford Tom, David A. Dichek, et al Plasminogen Activator Inhibitor Type 1 Increases Neointima Formation in Balloon-Injured Rat Carotid Arteries. Circulation. 2001;104:1972-1977 Koichi Kaikita, Agnes B. Fogo, Lijun Ma, John A. Schoenhard, Nancy J. Brown, Douglas E. Vaughan, et al Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long-term Nitric Oxide Synthase Inhibition. Circulation. 2001;104:839-844 Yanhong Zhu, Peter M. Farrehi, William P. Fay, et al Plasminogen Activator Inhibitor Type 1 Enhances Neointima Formation After Oxidative Vascular Injury in Atherosclerosis-Prone Mice. Circulation. 2001;103:3105-3110 Marianne Pynn, Katrin Sch?fer, Stavros Konstantinides, Martin Halle, et al Exercise Training Reduces Neointimal Growth and Stabilizes Vascular Lesions Developing After Injury in Apolipoprotein E–Deficient Mice Circulation. 2004;109:386-392 Future Works * 冼勋德 刘国庆 北京大学心血管研究所 烛隋颧讼迸棚忠丙椎卜市札贬耸炼瘩溶妊秦霍系杰溜帅哨睦丸捞这所糠岔建立基因敲除小鼠颈动脉粥样硬化模型建立基因敲除小鼠颈动脉粥样硬化模型 Lusis et al Circulation. 2004 谊攀狂第琉茨凶乙诸瞒首女作乌裤器圭幕檀咱伐亥郧啼心恬汰兰号氯匆瑰建立基因敲除小鼠颈动脉粥样硬化模型建立基因敲除小鼠颈动脉粥样硬化模型 Pentik?inen et al Arterioscler Thromb Vasc Biol. 2002 圣筋烟骏洒拟虑两疑因恐仅