磁共振波谱成像的naacr chocr比值在中年人高血压脑损伤的横断面研究-cross - sectional study of naacr chocr ratio by magnetic resonance spectroscopy in middle-aged hypertensive brain injury.docxVIP

万方数据万方数据目 录中文摘要············································································································1 英文摘要············································································································3 英文缩写············································································································5 研究论文 磁共振波谱成像的 NAA/Cr、Cho/Cr 比值在中年人高血压脑损伤的横断面研究 前言············································································································6 材料与方法································································································7 结果··········································································································10 附图··········································································································12 附表··········································································································18 讨论··········································································································20 结论··········································································································30 参考文献··································································································31综述 高血压和脑老化的氢质子磁共振波谱成像的研究进展及应用········36 致谢············································································································50 个人简历··········································································································52中 中 文 摘 要 PAGE 10万方数据 PAGE 10万方数据磁共振波谱成像的 NAA/Cr、Cho/Cr 比值在中年人高血压脑损 伤的横断面研究摘 要目的：以往的研究中已经对老年群体血压和年龄因素对脑的损伤进行 了探讨。本研究的主要目的是应用磁共振波谱成像(magnetic resonance spectroscopy, MRS)的 NAA/Cr、Cho/Cr 比值探究高血压与年龄在中年阶段 导致早期隐匿性脑损伤的关系。方法：2015.10-2016.1 从河北医科大学第二医院心血管内科门诊及体 检中心招募志愿者，均行常规颅脑核磁共振成像（magnetic resonance imaging, MRI）和多体素 2D-PRESS-144 序列。其中符合纳入标准的共 42 名，其中男性 18 例，女性 24 例，年龄在 45-59 岁之间，平均年龄 53.3±4.7 岁。其中 24 名高血压患者，18 名健康志愿者，分成高血压组和非高血压 组。感兴趣脑区分别为：胼胝体干（即，胼胝体体部）前