第7章抗胆碱酯酶药及胆碱酯酶复活药.pptVIP

第七章 抗胆碱酯酶药 和胆碱酯酶复活药;Cholinesterase cleans up unused acetylcholine, by breaking it down into its components acetate and choline. Neurons which produce acetylcholine are damaged in, with the result that levels of acetylcholine fall in the brain. Cholinesterase inhibitors may be useful in Alzheimers disease patients by allowing what acetylcholine there is to survive longer and be more effective. ;第一节 胆碱酯酶 ;第二节 抗胆碱酯酶药; 2. 作用机制 (1) 可逆性抑制胆碱酯酶 新斯的明+AChE→复合物→裂解出二甲氨基甲 酰化胆碱酯酶→胆碱酯酶解离速度慢——ACh堆积→拟胆碱作用 (2) 直接兴奋NM受体。 (3) 促进神经末梢ACh释放。 [临床应用 ] 1. 重症肌无力 2. 术后腹气胀、尿潴