丙戊酸钠联合癫痫平序贯治疗癫痫临床观察.docVIP

丙戊酸钠联合癫痫平序贯治疗癫痫临床观察 　　[摘要] 目的 观察丙戊酸钠联合癫痫平序贯治疗癫痫的临床疗效，探讨其有效性及安全性，以期更有效地控制癫痫发作。 方法 76例癫痫患者随机分为治疗组和对照组，治疗组在常规治疗基础上联合癫痫平的剂量调整，对照组为丙戊酸钠常规疗法。观测两组患者临床疗效、不良反应、治疗时间与发作频率的相互关系。 结果 治疗组（40例）有效控制发作，较对照组（36例）临床疗效显著提高，不良反应发生率降低；两组治疗后癫痫发作严重程度积分值比较，差异有统计学意义（P　　[关键词] 癫痫；丙戊酸钠；癫痫平； 序贯疗法； 疗效观察 　　[中图分类号] R742.1 [文献标识码] B [文章编号] 2095-0616（2014）16-58-03 　　Clinical observation of sequential therapy of valproate combined with Dianxianping tablet in treating epilepsy 　　LI Zuoji1，2 WANG Chunbo1 SUI Zhongguo1 XU Wen1 SUN Guizhen2 SU Zhenyu3 　　1.Qingdao University Medical College， Qingdao 266021， China； 2.The Peoples Hospital of Gaomi， Gaomi 261500， China； 3.Gaomi City Mental Health Center， Gaomi 261500， China 　　[Abstract] Objective To investigate the efficacy and safety of sequential therapy of valproate combined with Dianxianping tablet in treating epilepsy for more effective to control epilepsy. Methods 76 patients with epilepsy were randomly divided into treatment group（40 cases） and control group （36 cases）. The treatment group was given the treatment of sequential therapy of valproate combined with Dianxianping tablet，and the patients of control group were given the treatment of valproate. Clinical curative effect， adverse reactions， treatment time and seizure frequency relationships of two groups were observed. Results The treatment group could effectively control the seizures. The clinical efficacy of treatment group was better than that of control group， and the adverse reaction of the observation group was lower than that in the control group. After treatment， the difference of two groups seizure severity score was statistically significant （P0.05），具有可比性。 　　1.2 诊断标准 　　参照2001年国际抗癫痫联盟（ILAE）推荐的癫痫发作的分类方案[2]。根据临床症状并监测脑电图显示发作源于脑部两侧，具有癫痫的发作性、重复性、短暂性、刻板性为共同特征的全身性发作；并偶有持续状态发生；过去3个月内，平均每月发作≥2次；有完整门诊或住院病历记录。 　　1.3 排除标准[3] 　　有肝病或明显肝功能损害者；有药源性黄疸个人史或家族史者；有血液病、肾功能损害、器质性脑病者；有进行性神经系统疾病或精神障碍者；服用抗癫痫药可诱发或加重的患者；对丙戊酸钠过敏者；卟啉症患者；治疗依从性差者。 　　1.4 方法 　　对照组采用丙戊酸钠（山东仁和堂药业有限公司，小剂量递加法，开始时按0.2g，bid，一周后递增，至能