第七章 细胞质基质与胞内膜系统.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Synthesis and Insertion into the ER Membrane of the GLUT1 Glucose Transporter and Other Proteins with Multiple Transmembrane α-helical Segments. The N-terminal α helix functions as an internal, uncleaved signal-anchor sequence (red), directing binding of the nascent polypeptide chain to the rough ER membrane and initiating cotranslational insertion. Both SRP and the SRP receptor are involved in this step. Following synthesis of helix 2, which fun