烟草依赖是一种亟待防治的慢性疾病ppt课件.pptVIP

* * * * * * * * * * * * Key Point Nicotine stimulates dopamine release in areas of the brain that are believed to be involved in the reward and satisfaction effect associated with smoking. After inhalation, nicotine preferentially binds to nAChR located in the mesolimbic-dopamine system of the brain within seconds. Nicotine specifically activates ?4β2 nicotinic receptors in the ventral tegmental area (VTA), causing an immediate dopamine release at the nAcc. The dopamine release is believed to be a key component of the reward circuitry associated with cigarette smoking. Reference Picciotto M