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囊性纤维病抗生素的应用（英文PPT）Inhaled Antibiotics in Cystic Fibrosisppt课件
Maclusky et al. Patients received either tobramycin 80 mg t.i.d. or normal saline Patients were aware of their treatment regimen but the physicians were blinded Maclusky et al. 28 patients were enrolled,13 patients in the control group and 15 patients in the treatment group 1 patient was not colonized with Pa and was excluded from analysis, and 1 patient in the control group died at 13 months into the study Maclusky et al. Results FEV1 improved (p0.01) on treatment FVC improved (p0.05) on treatment no evidence of nephro- or ototoxicity Maclusky et al. 100 80 60 40 20 100 80 60 40 20 FEV1 % Predicted FVC % Predicted Treatment Months Follow Up 0 10 20 30 40 Ramsey et al. 71 patients enrolled into a double-blind, placebo-controlled, three period crossover trial to assess the efficacy and safety of aerosolized tobramycin. attempted to overcome some limitations of previous studies. double-blinded larger number of patients covered the taste of tobramycin Ramsey et al. Patients had FVCs greater than 40% and were colonized with Pa Randomly assigned to either tobramycin 600 mg t.i.d. for 28 days followed by placebo for 56 days (group 1) or placebo for 28 days followed by tobramycin for 56 days (group 2) To assess compliance quinine hydrochloride was added to both solutions and random urine samples were taken during the study Ramsey et al. 36 patients were assigned to group 1, and 35 to group 2 66 of the 71 patients completed the study Noncompliance ranged from 7 to 20% during the study and was comparable between the 2 groups Ramsey et al. FEV1 and FVC were both increased over placebo during the first 28 days (p0.015). During the three-period crossover the significance of the increase in FEV1 between treatment and placebo was greater (p0.005). A significant carryover effect was found for FEV1 (p0.009). 代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 Inhaled Antibiotics in Cystic Fibrosis By Tony S. Poteat, M.D. Resident
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