喹唑啉酮类新化合物的设计合成及其抗微生物相关研究.pdf

Abstract presence of 2翩methoxyethanol via cyclization to produce 7-fluoroquinazolin叶(3H}…one or 弘chloroquinazolin-4(3H)-one 1I-1a-b in high yield , and then compounds 1I-1a-b were 如rther treated with a series of alkyl dibromides to conveniently and efficiently afford bromides 11-2叫.丁he target quinazolinone azoles 11-3叫， 11-4叫，1I-5a-d， 116-a-d, 11-7a-b, 11斗a-b， 11-9a-b, 11… 10a-d and 11… lla-b were obtained by the reaction of bromides 11…2a寸 respectively