Fever病理生理 发热ppt课件.pptVIP

Fungi Pyrogenic components：whole body, Capsular polysaccharide and proteins Oral Candida albicans Candida albicans Spirochete Pyrogenic components：metabolic components and edotoxin Leptospira Treponema pallidum Plasmodium Pyrogenic components: merozoite and malarial pigment Plasmodium vivax merozoite Non-microbial pyretic substances 1、Antigen-antibody complexes 2、Steroid 二. Endogenous Pyrogens（EP） 产EP的细胞在PA诱导物的作用下，产生和释放的能引起体温升高的物质。 Pyrogenic activators(PA) IL-1 TNF INF IL-6 EPs Mononuclear/macrophages Other cells Tumor cells lipocyte？？？ 脂肪细胞能分泌包括IL-1, TNF-α在内的众多cytokine 肥胖患者体温较正常人高 三、Mechanisms Positive (+) Negative (-) 视前区-下丘脑前部 (POAH) Cold sensitive neurons + ---heat-production Heat sensitive neurons + ---heat-loss medial amygdaloid nucleus，MAN、ventral septal area，VSA、arcuate nucleus，ARC Thermoregulatory Center (Central mediators of fever)