Growth Factor receptor 3 Mutations in Epidermal Nevi and 成纤维细胞生长因子受体3基因突变与表皮痣ppt课件.pptVIP

Fibroblast Growth Factor receptor 3 Mutations in Epidermal Nevi and Associated Low Grade l Bladder Tumors.?Hernandez S, Toll A et al?JID (2007, July), Volume 127 ;INTRODUCTION ;Epidermal nevus;Seborrheic keratosis;Acanthosis Nigricans; FGFR3 DNA mutations are found in Skeletal dysplasias (exons 7, 10, 15), and the resultant constitutive kinase activity correlates with disease severity. The authors found a case of a 41 year old patient with a congenital widespread non epidermolytic keratinocytic Epidermal Nevi(in addition to 3 other literature reports). Patient had a history of low grade u