老年病人手术的麻醉精品ppt课件.ppt

NONVOLATILEANESTHETIC AGENTS Elderly patients require nearly 50% lower blood levels of propofol for anesthesia than younger patients thiopental sensitivity appears to be primarily due to pharmacokinetics factors Opioid sensitivity to fentanyl, alfentanil, and sufentanil is primarily pharmacodynamic Dose requirements for the same EEG end point using fentanyl and alfentanil are 50% lower in elderly patients volume of the central compartment and clearance are reduced for remifentanil Benzodiazepines diazepam the elimination half-life can be as long as 36–72 h Midazolam requirements