介入治疗时支架选择策略陈纪林ppt课件.pptVIP

Study;;;;Randomisation 1:1;;;SES in AMI Typhoon Trial To Assess The Use of the CYPHER? Sirolimus-eluting Stent (SES) in Acute Myocardial Infarction Patients Treated With Balloon Angioplasty;SES in AMI Typhoon study design;% 占患者总数的百分比;HORIZON 2年和TYPHOON 4年结果;A Prospective, Randomized Comparison of Paclitaxel-eluting TAXUS Stents vs. Bare Metal Stents During Primary Angioplasty in Acute Myocardial Infarction Gregg W. Stone MD For the HORIZONS-AMI Investigators ;3602 pts with STEMI with symptom onset ≤12 hours;1) Ischemia-driven TLR*;1年结果：TAXUS PES与Express BMS减少临床和造影再狭窄率，而死亡、再发心结梗死和支架内血栓形成发生率相似。 MACE：死亡、心肌梗死、卒中或支架内血栓形成;% of Patients;13(5.2%);Typhoon 研究小结;? Cordis Corporation 2008;? Cordis Corporation 2008;Objective: To demonstrate non-inferiority(and, if positive, superiority) of the NEVO? Stent compared with the TAXUS? Liberté? stent for the primary endpoint of 6-months in-stent late loss;Single De Novo Native Coronary Artery Lesion 28 mm in a 2.5-3.5mm diameter vessel;Primary Endpoint: 6-months in-stent late lumen loss (Angiographic);±0.31;P=0.075; Superiority of the NEVO ? stent over the TAXUS? Liberté? stents was reached with a highly significant difference (P0.001) between stents (6- month late loss 0.13 ±0.31 vs. 0.36 ±0.46mm) No stent thrombosis were observed in the NEVO ? group while 2 late thromboses despite dual APT occurred in the TAXUS? Liberté? group While not powered for clinical endpoints, in this study the rates of death, MI, and revascularization as well as the composite endpoints of TLF, TVF, and MACE all favored NEVO ? over TAXUS? Liberté?