烧伤脓毒症血浆生物标志物的临床分析及护理对策分析-clinical analysis and nursing countermeasures of plasma biomarkers in burn sepsis.docx

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烧伤脓毒症血浆生物标志物的临床分析及护理对策分析-clinical analysis and nursing countermeasures of plasma biomarkers in burn sepsis.docx

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烧伤脓毒症血浆生物标志物的临床分析及护理对策分析-clinical analysis and nursing countermeasures of plasma biomarkers in burn sepsis

缩略语表英文缩写英文全称中文全称APACHEacutephysiologyandchronichealthevaluation急性生理与慢性健康评分APTTactivatedpartialthromboplastintime活化部分凝血活酶时间AUCareaunderthecurve曲线下面积BSAburnsurfacearea烧伤面积COGclusteroforthologousgroupsofproteins同源蛋白质簇CRPC-reactionproteinC-反应蛋白DTTdithiothreitol二硫苏糖醇EDTAethylenediaminetetraaceticacid乙二胺四乙酸GOgeneontology基因本位学IAMiodacetamide碘乙酰胺iTRAQisobarictagsforrelativeandabsolutequantitation同位素相对标记与绝对定量技术LC-MSliquidchromatography-massspectrometry液相色谱串联质谱MODSmultipleorgandysfunctionscore多器官功能障碍评分NADPHnicotinamideadeninedinucleotidephosphate还原型烟酰胺腺嘌呤二核苷酸磷酸NAMLAAN-acetylmuramoyl-l-alanineamidaseN-乙酰胞壁酸-L-丙氨酸酰胺酶PCRpolymerasechainreaction多聚酶链反应PCTprocalcitonin降钙素原PGLYRPpeptidoglycanrecognitionprotein肽聚糖识别蛋白PMSFphenylmethanesulfonylfluoride苯甲基磺酰氟Prx-2Peroxiredoxin-2过氧化物还原酶-2ROCreceiveroperatorcharaeteristiccurve受试者工作特征曲线SIRSsystemicinflammatoryresponsesyndrome全身炎症反应综合征SCXstrongcationexchangechromatography强阳离子交换色谱SDSsodiumdodecylsulfonate十二烷基磺酸钠TEABtetraethylammoniumbromide四乙基溴化铵1ClinicalstudyonplasmabiomarkersofburnsepsisandanalysisofnursinginterventionsAbstractThekeytotreatsevereburnpatientssuccessfullyliesonaccurateinjuryjudgementandearlyfluidresuscitation,timelydetectionforburnsepsisfollowedbyrationalantibiotictherapy,aswellasremovalofnecrotictissueassoonaspossibleandacceleratinghealingandregenerationofburnwound.However,inclinicalpractice,thejudgmentofburnwounddepthcanbeinevitablyinfluencedbysubjectivefactors,andclinicalapplicationsofauxiliaryequipmentsalwaysconfrontlimitations.Intermsofburnconditionmonitoring,therearesomebiomarkersspecificforsomecertainkindoforganinjury,however,therestilllackadirectindicator,whichcantelltheoverallconditionofvariouscellsandorganspostburn.Whenitcomestothediagnosisofburnsepsis,duetothefeaturesoftheverydisease(whichincludesfastprogress,highmortalityrate,andinsidiousclinicalmanifestations)aswellasthelimitationsofclinicalmicrobiologicalculture,accurateandtimelydiagnosisofburnsepsisremainsamajorchallengeforcliniciansnowadays.Procalcitonin(PCT)i