射频消融治疗中超声温度影像与弹性成像的可靠性分析-reliability analysis of ultrasound temperature imaging and elastography in radiofrequency ablation.docxVIP

ABSTRACTRadiofrequencyablation(RFA)whichisinducedbyheattissuecoagulationnecrosisachievesthegoaloftreatmentoftumors.Ithasbeenconsideredtobeasafeandeffectiveminimallyinvasivetreatmentmethod.Successfulablationdependsonthetemperaturechangeofradiofrequencyablationzone.Ultrasonicimagingiscurrentlythemostcommonlyusedinmedicalmonitoring.Thepurposeofthisstudyistoexploretheapplicabilityaboutthetemperatureandelasticityimagingmethodunderdifferentpower,whichgivessomereferencetofutureclinicalresearch.Inthisstudy,preparesomeliversamplesforablationunderdifferentpower(10w,50w).Theheatingtimewas3minutes.TheRFablationprocesswasmonitoredbyadiagnosticultrasoundimagerandtheinformationwaspostoperativelycapturedforfurthertemperatureandelasticityimageanalysis.TheinfraredthermometrywasconcurrentlyappliedtoprovidetemperaturechangecalibrationduringtheRFA.Resultsfromthisstudydemonstratedthattheechoshiftimagingisvalidunder10WRFexposure,buttheablationzoneisnolongerconsistentwiththereferenceunderthehighRFexposure.Theelasticitychangecouldwellreflecttheablationzoneunder50Wexposure;inthecontrary,underlowexposure,thethermallesioncannotbewelldetectedduetothelimitedrangeoftemperatureelevationandincompletetissuenecrosis.Thetemperatureimagingbasedonthechangesinthebackscatteredenergyshowedgoodconsistencynomatterwhatthepowerwas.Ithasbetterstabilitythanecho-shiftimageandhasnolimitsastheelasticityimagingwhichisonlysuitedunderhighpower.Itcanbeareliabletooltodescribethetemperatureprofileduringradiofrequencyablation.Thisisthefirsttimetodiscussthereliabilityamongthethreemethods.Wehavedemonstratedthatthediagnostic-ultrasoundbasedtemperatureandelastographyisvalidforthemonitoringofRFablationprocess.Thetemperatureestimationbasedontheechoshiftscanwellreflectmild-powerRFablationdynamics,theotheralgorithmbasedontheCBEhasgoodapplicabilityinhighandlowpower.Whereastheelastic-changeestimationcanwellpredictthetissuenecrosis.ThisstudyprovidesadvancestowardsusingdiagnosticultrasoundtomonitorRFAorotherthermal-basedinterventions