生物流变特性测试方法及应用分析-test method and application analysis of raw material flow variation characteristics.docx

哈尔滨工业大学工学博士学位论文 哈尔滨工业大学工学博士学位论文 Abs Abstract - - PAGE VIII - - - III - 测试特性模型，建立了高灵敏度、高可靠性的库特式生物流体流变学特性测试 系统和动态数据建模平台，采用应力驱动、实时频率扫描、小振幅振荡和强迫 振荡四种模式实现生物流体流变学特性测试及动态数据建模。 论文对提出的稳态剪切速度衰减血流变测试方法和激光衍射细胞流变学特 性测试方法进行了实验验证，针对目前非牛顿流体流变特性测试仪器无法标定 以及测试结果无法溯源等问题，研制了一种稳定可靠的非牛顿流体标准物质， 提出了非牛顿流体标定方法。 完成了基于稳态剪切速度衰减测试方法的血流变测试系统应用研究。系统 采用提出的速度衰减法锥板测试技术实现全量程、逐点扫描、快速、稳态的血 流变特性测量，具有自动加样、自动混匀、自动测试、自动清洗、液面感应等 先进功能，具有非牛顿流体标准物质标定和校准功能。 完成了基于双磁路小振幅振荡测试方法的凝血测试系统应用研究。利用提 出的双磁路磁珠振荡法测量原理实现血液凝固过程中的流变特性功能测试。系 统具有先进的三维空间加样系统、驱动器内置点到点功能、S 曲线加速、直线/ 圆弧插补运动功能以及微弱信号采集放大功能。系统具有功能强大、实时多任 务操作、检测速度快、精度高等特点。 本论文的研究为生物流变学特性测试方法及应用奠定了必要的理论基础， 对于推动我国生物流变学特性测试技术研究有着重要的指导意义。 关键词：非牛顿流体；流变学特性；生物医学检测；测试仪器；精度评定 Abstract Rheology is a science that studies the time-related deformation and flow of non-Newtonian fluids under the conditions of stress, strain, and temperature. It is an interdisciplinary subject which includes some parts of physics, mechanics, medicine, biology, and engineering. The flow of viscoelastic fluids, viscoplastic fluids, bloods, and most of biofluids demonstrates the characteristics of non-Newtonian fluid. The testing of some rheological characteristics, such as the rheological characteristics of non-Newtonian fluids, mechanical analysis of fluid flow and deformation, constitutive equations of fluids, parameters and functions of material, viscosity-temperature characteristics of fluids, flow curve, coagulability, viscoelasticity, and thixotropy, demands prompt solution. Especially in the field of biomedical engineering, the test problems about the biorheological characteristics, such as the dynamics of blood flow, deformation laws of blood cell, mechanical properts of blood, other body fluids, and all kinds of soft and hard tissues, and relations between the rheological characteristics of biofluids and illnesses, are raised in succession. Hemorheology, cell rheology, and the rheological mechanism and parameter measurement during the process of blood coagulation, have att