十字交叉沟通微通道芯片的微液滴生成分析-analysis of droplet generation in cross-linked microchannel chips.docxVIP

modification.Whentwo-phaseflowwereappliedwithinthecrossedmicrochannels,gas-filledandliquid-filledrespectively,withaflowratioof2/3~9/10,thedevicepresentedapictureofmicrodropletscontinuouslygenerated.Thesizesofdropletswereincreasedastheflowratiodecreased,andtheirgenerationfrequencycouldbereachedmorethanmoderatethroughput.Secondly,forthecaseofthemulti-cross-overmicrochannledeviceinwhichparallelmulti-through-holeswerefabricatedinalongonesinglechannel,theresultsshoweditcouldalsogeneratemicrodropletsineachthrough-hole,similartothatoftheabove-mentionedonesinglecross-over.However,theemergeoffirstdropletfromeachthrough-holetoitsdownstreammicrochannelwasdelayedsequentiallyalongthepressuredropinthegas-filledchannel,thetimedifferencebetweentheneighboringparallelmicrochannelsdependedonthespacingbetweentheneighboringthrough-holesandtheirgeometricconditions;whenthespacingof100~200μm,thetimedifferencewasestimatedabout0.5s.Thirdly,thebehaviorsofmicrodropletgenerationinsuchacross-overmicrochannelswithonesinglethrough-holewerefurtherstudiedunderthemanipulationoftwo-phaseofliquid-liquid.Inexperiments,onechannelwasinjectedintowithlecithin(oil)solution,theotherwithpurewater.Theresultsshowedthatinthe4groupsofmicrochanneldevices(withcross-overdiametersof20μm,40μm,60μm,80μm,respectively),onlythegroupsof60μmand80μmcouldgeneratedropletsattheir1.5mmdownstreamofthethrough-hole,withameansofoil-in-water.Ingeneral,totherobustgenerationofmicrodropletsinsuchcase,theflowrateofoilphaseshouldbeabout1μL/minlargerthanthatofwater;meanwhile,thedropletvolume,homogeneousenoughthus-generated,strictlydependedinproportionaltoontheoil/waterflowratio.However,whentheoil/waterflowratiofellintotherangeof10/9~15/14μL/min,tinydroplets(oil-in-water)couldbeseenrapidlygeneratedwithadiameterof3~5μm.Finally,arudimentsoftwareinterfacetotheintegrationofseveralprocessesrelatedtothemicrodropletgenerationandanalysiswasdevelopement,basedontheobservationofdropletsgenerationwithmicroscopicvideosystems,microparticleimagevelocimetry