护理干预对重症肺炎患者肺成纤维细胞的生物学活性的影响.docVIP

护理干预对重症肺炎患者肺成纤维细胞的生物学活性的影响 　　[摘要] 目的 研究重症肺炎患者肺成纤维细胞（LFB）的生物学活性及护理措施。 方法 选择我院于2014年1月～2016年1月来就诊的36例重症肺炎患者作为研究对象。对患者给予综合护理，分析其护理前后LFB的生物学活性。 结果 护理后患者肿瘤坏死因子-α（TNF-α）、转化生长因子-β（TGF-β）、人基质金属蛋白酶-9（MMP-9）的表达水平均显著低于护理前，Ⅰ型胶原蛋白含量及α-SMA显著高于护理前；护理后患者各项生活质量指标均显著高于护理前；护理后患者SAS及SDS评分均显著低于护理前，差异均有统计学意义（P均0.05）。 结论 对重症肺炎患者施以全面有效的精心?o理，对患者的生活质量，患者的不良情绪调整等综合效果显著，有效促进患者康复，安全可靠，值得临床推广。 　　[关键词] 重症肺炎患者；肺成纤维细胞；生物学活性；护理措施 　　[中图分类号] R473.5 [文献标识码] B [文章编号] 1673-9701（2017）14-0156-04 　　[Abstract] Objective To study the biological activity of lung fibroblasts （LFB） and nursing measures in patients with severe pneumonia. Methods 36 patients with severe pneumonia who were treated from January 2014 to January 2016 in our hospital were selected as the subjects. The patients were given comprehensive nursing and the biological activity of LFB before and after nursing was analyzed. Results The expression levels of tumor necrosis factor-α （TNFα）， transforming growth factor-β （TGF-β） and human matrix metalloproteinase-9 （MMP-9） after nursing were significantly lower than those before nursing，and the typeⅠcollagen content and α-SMA were significantly higher than those before nursing. The quality of life indexes of patients after nursing were significantly higher than those before nursing. The SAS and SDS scores of patients after nursing were significantly lower than those before nursing（P0.05）. Conclusion Comprehensive and effective nursing applied in the patients with severe pneumonia has significant effect on the quality of life and regulating the poor mood of the patients. And it plays an effective role in promoting the rehabilitation of patients，which is safe and reliable and worthy of clinical promotion. 　　[Key words] Severe pneumonia patients； Lung fibroblasts； Biological activity； Nursing measures 　　重症肺炎有诸多的发病因素，同时还有较多并发症， 并伴随休克、多脏器功能及呼吸衰竭等，在临床有较大的治疗难度[1]。有报道称[2]，对重症肺炎患者不但要积极治疗，而且有效的干预护理措施能在很大程度上帮助患者恢复，改善患者肺纤维化程度，提高患者免疫力。有研究发现[3]，肌纤维母细胞作为其纤维化进程中活跃性最强的细胞，能大量分泌细胞因子、生长因子及炎性间质，是导致患者肺纤维化的关键因素。本文