自身免疫性甲状腺炎约翰霍普金斯医学院ppt课件.ppt

Patrizio Caturegli, MD MPH Associate Professor of Pathology, Endocrinology, Immunology;The endocrine glands;6 “Classic” Endocrine Glands;6 “Classic” Endocrine Glands;Autoimmune Endocrinopathies;Definition of Autoimmune Disease;Autoimmunity: the beginnings;Description of Autoimmune Endocrinopathies;Diseases that will be discussed;Diabetes Mellitus (DM);Type 1 DM (beta cell loss);Genetic Susceptibility;Genetic Susceptibility;Odds of developing type 1A DM;Pathogenesis;Pathogenesis;Laboratory Assessment of autoimmune endocrinopathies;Modern diabetes Ab tests;DM progression based on Abs;Autoimmune Thyroid Diseases;Big, smooth and soft;Graves disease;TSH-R antibodies: Clinical Utility;Hashimoto thyroiditis;Hashimoto’s thyroiditis (various forms);Classic Hashimoto’s thyroiditis;Hashimoto’s thyroiditis: pathogenesis;TPO antibodies: Clinical Utility;TG antibodies: Clinical Utility;Addison disease;Addison disease;Addison disease;Autoimmune hypoparathyroidism;Alimohammadi, NEJM 2008;Autoimmune Hypophysitis;Reticulin staining;52;Striking temporal association with pregnancy;Clinical Presentation of Hypohysitis:similar to that of all non hormone secreting pituitary masses;the CTLA-4 connection;APS-1 (or, APECED);APS-1 (or, APECED);APS-2 (Schmidt-Carpenter syndrome);IPEX syndrome