支架内血栓李建平课件.pptVIP

支架内血栓In-Stent Thrombosis;;支架内血栓的预后;支架内血栓发生时间;Stent Thrombosis (%);;DES肯定的ST发生率:Bern - Rotterdam Cohort Study Daemen, Wenaweser et al. Lancet 2007;369:667-78;;0.52% (95% CI=0.42-0.62)/ year between 30 days and 5 years;;Early Stent Thrombosis; Very Late ST 1 Year (Per Protocol) ;;Cumulative Incidence of Definite STin LEADERS (BES vs. SES)Windecker et al. Lancet, 2008, 372, 1163-;Overall Incidence of ST with DES;High Risk of ST in All-Comer Patient Population and STEMI Patients;支架内血栓的病因;早期支架内血栓的预测因素:残留夹层/撕裂;早期支架内血栓IVUS预测因素 With the Use of Sirolimus-Eluting StentsFujii K et al. J Am Coll Cardiol 2005;45:995-8;支架内血栓预测因素药物反应异常 Wenaweser P et al. JACC 2005; 45(11):1748-52 ;服药后血小板活性与DES ST的关系Buonamici P et al JACC 2007;Iakovou et al JAMA 2005;支架内血栓发生时的抗血小板治疗 Bern-Rotterdam Cohort Study @ 5 YearsWenaweser P et al. ESC 2008;Triton TIMI 38 – Prasugrel vs. Clopidogrel in ACS Patients With Stents Wiviott SD et al. Lancet 2008;371:1353-63;Park et al Am J Card 2006;Roy et al J Interv Card 2007;Park et al Am J Card 2006;Impact of Thrombus Burden on Risk of ST With DES in Patients With STEMISianos G et al. J Am Coll Cardiol 2007;50:573-83;Kuchulakanti Circ 2006;晚期支架内血栓的可能原因;多聚物高敏;获得性晚期支架贴壁不良;Cook et al. Circulation 2007;小结; 支架内血栓的预防;;;;;;;;;;DES 风险 获益