深部静脉血栓的遗传危险因素课件（英文）.pptVIP

Toshiyuki MIYATA, PhD National Cardiovascular Center Research Institute, Osaka, Japan;Advanced age is a risk for venous thromboembolism (VTE);Risk factors for venous thromboembolismN Engl J Med, 358, 1037-52, 2008;;;;Kimura et al., Blood, 2006;Protein S K196E as a Risk for VTE;;;Heterozygotes;Acquired factors influencing plasma protein S activity; PROS1 K196E mutation is a genetic risk factor for venous thromboembolism (VTE) in Japanese. A missense mutation causing Lys196 to be replaced by Glu is located within the 2nd EGF-like domain. The odds ratio of the mutant E allele for VTE was 5.58.