《信号转导》课件.pptVIP

synthesized in adrenal medulla; belongs to catecholamines (儿茶酚胺）; target cells include liver, skeletal muscle, heart muscle and adipose; released in response to acute stress Epinephrine 肾上腺素 signal Epinephrine 肾上腺素 signaling pathway cAMP Epinephrine 肾上腺素 signaling pathway (2) Activation of cAMP-dependent protein kinase (PKA) Inactive PKA: Regulatory (R) subunits: auto-inhibitory domains buried catalytic (C) subunits: substrate-binding sites blocked by R subunits R subunits: autoinhibitory domains buried Active PKA C subunits open substrate binding sites A catalytic subunit of PKA A