慢性乙型肝炎诊断课件.pptVIP

Resistance to Lamivudine and Adefovir in HBeAg-negative CHB The incidence of the emergence of treatment-resistant mutations increases over time on treatment.1 Although much less common than with lamivudine, a small but significant number of patients develop resistant mutations with adefovir, and this number increases over time.2 1. Pooled data from Papatheodoridis et al. Hepatology 2002;Di Marco et al. Hepatology 2004; 2. Hadziyannis et al. J Hepatol 2004 Abstr. 30 31 血清胆红素：通常血清胆红素水平与肝细胞坏死程度有关，但需与肝内和肝外胆汁淤积所引起的胆红素升高鉴别。肝衰竭患者血清胆红素常较高，升高水平和速度是判断预后的重要指标之一。 生物化学诊断 凝血酶原时间（PT）及PTA：PT是反映肝脏凝血因