利尿药及降血糖药ppt课件.pptVIP

Medicinal chemistry;Chapter 10 Diuretics and Synthetic Hypoglycemic Drugs;Section 1 Hypoglycemic Drugs;Definitions ;Biochemistry and Pathogenesis of Diabetes;Classifications ; Mechanism of Action; Physical-Chemical Properties; Structure-activity Relationships;Many simple substituents on the sulfonyl aromatic ring are active. The p-(β-arylcarboxamidoethyl) grouping seen in second generation compounds is consistent with high potency. It is thought that the spatial relationship between the amide nitrogen of the substituent and the sulfonamide nitrogen is important. ; Tolbutamide; Propert