2型糖尿病患者HbA1c血脂水平与颈动脉内膜中层厚度相关性研究.docVIP

2型糖尿病患者HbA1c血脂水平与颈动脉内膜中层厚度相关性研究 　　【摘要】 目的：探?2型糖尿病（T2DM）患者糖化血红蛋白A1c（HbA1c）、血脂水平与颈动脉内膜中层厚度（CIMT）的相关性。方法：选择自2015年2月-2017年2月笔者所在医院内分泌科住院并确诊为T2DM的207例患者，根据颈部血管彩超测得CIMT的结果分为正常组（n=59）、增厚组（n=122）及斑块组（n=26），比较三组一般临床资料信息，利用Pearson相关分析探讨HbA1c、血脂水平与CIMT严重程度关系。结果：CIMT正常组、增厚组、斑块组三组间糖尿病病程、高血压病、HbA1c、LDL-C、HDL-C、TC、TG差异具有统计学意义（P0.05）；Pearson相关分析示，HbA1c、LDL-C、TC、TG与CIMT呈正相关（P0.05），HDL-C与CIMT呈负相关（P0.05）。结论：检测HbA1c、血脂水平对CIMT增厚具有较好的预测价值。 　　【关键词】 2型糖尿病； 颈动脉内膜中层厚度； 糖化血红蛋白； 血脂 　　doi：10.14033/j.cnki.cfmr.2017.30.005 文献标识码 A 文章编号 1674-6805（2017）30-0010-02 　　The Relationship between HbA1c，Lipid and Carotid Intima-media Thickness in Type 2 Diabetes Mellitus Patients/ZHONG Jiao.//Chinese and Foreign Medical Research，2017，15（30）：10-11 　　【Abstract】 Objective：To observe the relationship between hemoglobin（HbA1c），lipid and carotid intima-media thickness（CIMT） in type 2 diabetes mellitus（T2DM） patients.Method：207 cases with T2DM were selected to the endocrinogical department of our hospital from February 2015 to February 2017，all subjects received neck vascular ultrasound examination.Patients were divided into three groups based on the CIMT value：normal group（n=59），thickening group（n=122） and plaque group（n=26）.Basic clinical information among the three groups were compared.The relationship between the HbA1c，lipid levels and the severity of CIMT was observed by Pearson correlation analysis.Result：The increasing of CIMT was associated with disease course，hypertension，HbA1c，LDL-C，HDL-C，TC and TG，the differences were statistically significant（P0.05）.Pearson correlation analysis indicated that HbA1c，LDL-C，TC，TG levels were positively correlated with CIMT（P0.05），HDL-C was negatively correlated with CIMT（P0.05）.Conclusion：It is proved that the detection of HbA1c combined with lipid has a higher predictive value in the prediction of CIMT. 　　【Key words】 Type 2 diabetes mellitus； Carotid intima-media thickness； HbA1c； Lipid 　　First-author’s address：The First People’s Hospital of Jingzhou City，Jingzh