COX2和Bax在非小细胞肺癌中表达及意义.docVIP

COX2和Bax在非小细胞肺癌中表达及意义 　　【摘要】 目的 探讨非小细胞肺癌(NSCLC)中环氧化酶-2(COX-2)和Bax的表达及其临床意义。方法 采用免疫组织化学方法检测57例NSCLC癌组织（腺癌/鳞癌）、相应配对的15例正常组织及57例淋巴结COX-2蛋白和Bax蛋白的表达水平，计算其阳性百分比进行相关性分析。结果 NSCLC组织中COX-2蛋白表达高于癌旁正常组织(P0.05)；Bax蛋白表达低于癌旁正常组织(P0.05)。结论 COX-2在NSCLC尤其是肺腺癌中表达上调,Bax蛋白在NSCLC组织中表达过低，COX-2可能通过降低Bax表达，抑制细胞凋亡参与NSCLC的发生、发展。? 　　【关键词】 非小细胞肺癌；环氧化酶-2；Bax?? 　　Expression and significance of cyclooxygenase-2 and apoptosis inhibitor-Bax in Non-small cell lung cancer TONG Xu, SONG Zhuo.The Third Affiliated Hospital of Qiqihar Medical College. Heilongjiang 161000, China? 　　【Abstract】 Objective To investigate the expression of cyclooxygenase-2(COX-2) and Bax protein in non-small cell lung cancer(NSCLC) ,and its clinical significance and correlations of COX-2 and Bax.Methods Samples were obtained from 57 cases NSCLC tissues(including adenocarcinoma and squamous cell carcinoma)，15 sampls nomal lung tissues and 57 samples Lymphoid tissue. The expression level of COX-2 protein and Bax protein in these samples were examined by immunohistochemistry. The relationship between COX-2 and Bax were analyzed by positive percentage. Results The expression of COX-2 protein in NSCLC tissues is higher than nomal tissue which were obained nearly (P0.05); The expression of Bax protein in NSCLC tissues was lower than nomal tissue which were obained neraly (P0.05).there was relationship between COX-2 and Bax(P0.05). Conclusions The expression of COX-2 protein is up-regulated in NSCLC tissues, particularly in adenocarcinoma. The expression of Bax proiein is over-low in NSCLC tissues. COX-2 may participate in development and progression of NSCLC by lower expression of Bax inducing cell apoptosis.? 　　【Key words】 Non-small cell lung cancer; cyclooxygenase-2; Bax 　　? 　　肺癌的发病率和死亡率目前已经排在各种恶性肿瘤的第一位，严重威胁着人类的健康。为了提高肺癌患者的生存率,研究者们致力于找到一种能够早期诊断、治疗和精确评价预后的方法。目前的研究认为,COX-2在多种恶性肿瘤中高表达，参与肿瘤的发生、发展和转移。某些COX-2抑制剂已表现出明确的抗肿瘤作用，并且已经应用于肿瘤的治疗。但COX-2在肿瘤中的致癌机制尚不完全明确。Bax为Bcl-2家族成员,为凋亡促进基因，当Bax细胞内过表达时，细胞对死亡信号的反应增强，细胞死亡增多，因此Bax获得了一个“死亡激动剂”