ICAM1在乳腺浸润性导管癌中表达情况初步研究.docVIP

ICAM1在乳腺浸润性导管癌中表达情况初步研究 　　(1.杭州市中医院,浙江 杭州 310006, 2.浙江大学医学院附属第二医院,浙江 杭州 310009) 　　摘 要:目的:测定ICAM-1在乳腺浸润性导管癌(IDC)中的表达情况,并探讨其在乳腺IDC进展中的意义。方法:应用免疫组织化学方法研究49例乳腺IDC标本中不同组织成分ICAM-1的表达情况,并统计分析其与淋巴结转移、组织学分级及TNM分期之间的关系。结果:ICAM-1在乳腺IDC癌巢中的表达强度明显低于癌旁正常乳腺导管上皮(P0.05)及癌间质成分(P0.05),ICAM-1在乳腺IDC癌巢中的表达阳性率亦明显低于正常乳腺导管上皮(?P?0.05)。ICAM-1在乳腺IDC癌巢中的表达阳性率与淋巴结转移呈负相关(?r?s?=-0?312, ?P?0.05),而与组织学分级及TNM分期无关。结论:ICAM-1的表达水平在乳腺IDC癌巢中与癌旁正常乳腺导管上皮中明显不同, ICAM-1在乳腺IDC中的表达缺失或下调可能更易于肿瘤的淋巴结转移。对ICAM-1的作用机制的深入研究有可能使其成为乳腺IDC患者个体化治疗的新靶点。 　　关键词:ICAM-1;乳腺浸润性导管癌;淋巴结转移? 　　中图分类号:R655.8 文献标识码:B 文章编号:1673-7717(2010)04-0799-03 　　Expression of ICAM-1 and Its Clinicopathological Significance in Invasive Ductal Carcinoma (IDC) of Breast 　　HE Jun?ling1, CHEN Li2, REN Xing?chang1, XU Hai?bin1 　　(1. Hangzhou Hospital of Chinese Medicine, Hangzhou 310006, Zhejiang, China; 　　2. The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China)? 　　Abstract:?Objective:? To study the relationship between expression of ICAM-1 and clinicopathological findings in patients with IDC of breast. ?Methods:? Immunohistochemical assessment of ICAM-1 was performed on different tissues of 49 IDC cases. Furthermore, their relationship with clinicopathological factors such as lymph node metastasis, histological grade and TNM stage were considered from a statistical viewpoint. ?Results:? Expression level of ICAM-1 in cancer nest was lower than that in cancer stroma and normal ductal epithelium in 49 IDC samples, and the positive rate of ICAM-1 expression in cancer nest was also lower than that in normal ductal epithelium. Immunohistochemical staining against ICAM-1 in 49 IDC specimens showed significant negative correlation between ICAM-1 expression and axillary lymph node metastasis , other than histological grade and TNM stage. ?Conclusion:? This study demonstrates that expression intensity of ICAM-1 is different obviously in cancer nest and normal ductal epithelium, low expression level of