CA125及半衰期对卵巢癌诊断及监测评价.docVIP

CA125及半衰期对卵巢癌诊断及监测评价 　　摘要：目的 探讨血清CA125及其半衰期在卵巢癌诊断和疗效观察中的临床价值。方法 采用酶联免疫吸附法测定45例卵巢良性肿瘤，50例原发性卵巢癌患者血清CA125水平并计算CA125半衰期。结果 卵巢癌患者血清CA125浓度明显高于卵巢良性肿瘤患者，P 65u/ml为判断标准，诊断卵巢癌的特异性及敏感性均在90%以上。手术后残留病灶的大小与血清CA125浓度下降有关系，当残留病灶2cm时，其CA125浓度下降的程度明显低于残留病灶20d时，平均复发时间（14.33±7.93）月，前者复发率是后者的4.44倍。2例二探术前测血清CA12565u/ml，术中探查病灶直径分别为3cm、4cm，有6例CA125浓度在30～65u/ml，其中4例病灶直径为1cm、2cm、2cm、3cm，另外2例二探术为阴性。结论 血清CA125检测对卵巢癌的诊断具有较高的诊断价值，其CA125半衰期对病情的观察、疗效的检测及预后的判断有较高的临床参考价值。 　　关键词：卵巢癌；CA125；半衰期；诊断；预后 　　中图分类号：R737.31 文献标识码：A 　　Clinical Significance of Serum CA125 and Its Half-life Analysis in Diagnosis and Prognosis of Ovarian Cancer 　　LI Zhu-yan，CAI Hong-bing 　　（Department of Gynaecology，Affiliated Shiyan Peoples Hospital of Hubei Medical College，Shiyan 442000，Hubei，China） 　　Abstract：Objective To evaluate the value of serum CA125 and its half-life as amarker in monitoring the response to treatment and prognosis of advanced ovary cancer.Methods ELISA was used to detect the levels of serum CA125 and its half-life in 45 patients with ovary benign tumor and 50 ovary cancer. Results The serum CA125 levels in advanced ovary cancer patients were significantly higher than that of ovary benign tumor patients， P65u/ml have foci whose diameter is 3cm or 4cm. When CA125 levels between 35 and 65 u/ ml，there were 4 patients whose foci were 1cm，2cm，2cm and 3cm， another 2 patients was negative in second-look.Conclusion This suggested serum CA125 levels and its half-life had more reliable value. If used clinically， it may help to estimate of recurrence of ovarian cancer in time so as to take corresponding treating measures early. 　　Key words：Ovarian cancer； CA125；Half-life； Prognosis 　　卵巢癌在女性生殖器管肿瘤中发病率占第三位，但其死亡率却占第一位，其死亡率高居不下的原因是早期诊断较困难，约半数以上的卵巢癌发现时已属晚期，治愈率低，5年生率在25%～30%[1]之间。为提高患者的生存率，准确的评价治疗效果，及早发现肿瘤尤为重要。CA125是卵巢肿瘤细胞表面相关抗原，可以进入体循环。因此，患者血清CA125的含量，可以作为卵巢癌临床诊断的一种指标。本资料研究了CA125及其半衰期在卵巢癌诊断中的价值，以及在疗效的评价、预后的判断、术后监测中的作用。 　　1资料与方法 　　1.1一般资料 经手术和病理证实卵巢良性肿瘤45例，平均年龄（41.6±21.36）岁，卵巢囊肿23例，浆液性囊腺瘤9例，粘液性囊腺瘤8例。上皮性卵巢癌共50例