MCP1对梗阻性积水肾脏功能评估价值.docVIP

MCP1对梗阻性积水肾脏功能评估价值 　　[摘要] 目的 探讨MCP-1对梗阻性积水肾脏功能的评估价值。方法 应用B超对32名患者的双肾进行检测,分析肾积水的程度。应用酶联免疫吸附法(ELISA)检测病肾肾盂尿MCP-1水平,检测结果与B超对肾积水程度的分级作相关分析。结果 B超诊断重度肾积水4例,中度肾积水16例,轻度肾积水12例。病肾肾盂尿MCP-1水平随分级的增加而递增,在各分级组间比较均有显著性差异(P0.01)。经Spearman秩次相关分析,病肾肾盂尿MCP-1水平与分级密切正相关,有显著性差异(P0.001)。结论 病肾肾盂尿MCP-1的检测对梗阻性积水肾脏功能损害程度有较好的评估价值。 　　[关键词] MCP-1; B超; 肾积水 　　[中图分类号] R692.2 [文献标识码] A [文章编号] 1673-9701(2010)03-25-03 　　 　　Value of Monocyte Chemotactic Protein-1 in Renal Function Evaluation in Obstructive Hydronephrosis 　　LI Zhilong REN Laicheng 　　The Second Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China 　　 　　[Abstract] ObjectiveTo discuss the value of monocyte chemotactic protein-1(MCP-1) in the renal function evaluation in obstructive hydronephrosis. MethodsRenal B ultrasound was performed in 32 patients and they were classified according to the degree of hy- dronephrosis. Urine MCP-1 concentration of hydronephrotic kidneys was detected by Enzyme-linked immuno-sorbent assy(ELISA)and Spearman’s correlation test was used to compare grades of hydronephrotic kidneys. ResultsUltrasonic diagnosis showed severe- grade hydronephrosis 4 patients,moderate-grade hydronephrosis in 16 and mild- grade hydronephrosis in 12. There was a significant difference between the grades and the MCP-1 urine concentration of hydronephrotic kidneys(P0.01). Spearman’s correlation test showed MCP-1 was positively correlated closely with grades,with a significant difference(P0.001). ConclusionMCP-1 urine concentration of hydronephrotic kidneys may evaluate damage degree of renal function. 　　[Key words]Monocyte chemotactic protein-1; B-ultrasound; Hydronephrosis 　　 　　肾积水是临床上常见的肾功能不全就诊原因之一,长期肾积水多合并有不同程度的肾脏功能损害。此外,由于肾积水早期多无明显症状,多数患者因此贻误治疗时机,直至肾积水造成肾体积增大、腰酸、腰痛、感染以及肾结构破坏,严重者将导致患肾的肾功能不全,甚至出现肾功能衰竭时,人们才发现肾积水的存在。因此,肾积水的病因诊断和肾功能损害程度的评估对于早期发现肾积水,早期手术和挽救有功能的肾脏至关重要[1]。现收集我院2008年11月～2009年6月B超诊断为肾积水32例,分析肾积水的程度。并应用酶联免疫吸附法(ELISA)检测病肾肾盂尿MCP-1水平。从而探讨MCP-1对梗阻性积水肾脏功能的评估价值。 　　1 材料与方法 　　1.1 临床资料 　　1.1.1 对象选择