不同剂量美托洛尔治疗心肌梗死疗效及对患者心功能心率影响研究.docVIP

不同剂量美托洛尔治疗心肌梗死的疗效及对患者心功能、心率的影响研究 　　摘要：目的 探讨不同剂量美托洛尔治疗心肌梗死的疗效及对患者心功能、心率的影响。方法 从2014年1月～2016年12月在本院接受治疗的心肌梗死患者中随机选取116例作为研究对象，按照随机数字抽取表法进行分组，两组各58例，其中A组患者在常规综合治疗的基础上采用高剂量美托洛尔治疗；而B组患者则采用低剂量美托洛尔治疗，对两组患者治疗前后胸痛发作次数及持续时间进行分析，并观察心率、心功能改善情况等。结果 治疗后对照组和观察组胸痛发作次数及持续时间均降低，其中以观察组改善程度更加显著，P0.05；观察组患者左心室射血分数显著高于对照组，而左心室收缩末期容积显著低于对照组，P0.05。结论 对心肌梗死患者采用高剂量美托洛尔治疗利于获得较高的疗效，利于改善患者心功能，且心率稳定，安全性，值得推广应用。 　　关键词：美托洛尔；心肌梗死；心功能 　　中图分类号：R542.2 文献标识码：A 文章编号：1006-1959（2017）22-0073-02 　　Abstract：Objective To investigate the effect of different doses of metoprolol on myocardial infarction and its effect on cardiac function and heart rate.Methods From January 2014 to December 2016，116 patients were randomly selected from our patients with myocardial infarction.The patients were divided into two groups according to the random number extraction method.Two groups of 58 cases，of which group A patients in the conventional comprehensive treatment based on the use of high-dose metoprolol treatment； and group B patients were treated with low-dose metoprolol，the two groups of patients before and after treatment of chest pain episodes and duration of the analysis，and observe the heart rate，heart function improvement and so on.Results After treatment，the number and duration of chest pain were decreased in the control group and the observation group，the improvement degree of the observation group was more significant，P0.05；the left ventricular ejection fraction of the observation group was significantly higher than that of the control group，while the left ventricular end-systolic volume significantly lower than the control group，P0.05. Conclusion The high dose of metoprolol in patients with myocardial infarction can improve the curative effect and improve the heart function，and the heart rate is stable and safe.It is worthy to be popularized and applied. 　　Key words：Metoprolol；Myocardial infarction；Cardiac function 　　心肌梗死主要是由于心肌缺血引起的心肌急性?乃溃?主要表现为胸骨后剧烈疼痛、循环功能障碍等，给患者带来巨大的痛苦[1]。急性心肌梗死在老年群体中发病率较高，如何进行有效的治疗成