不同剂量131I对分化型甲状腺癌患者血清中TH水平及生活质量影响.docVIP

不同剂量131I对分化型甲状腺癌患者血清中TH水平及生活质量的影响 　　摘 要 目的： 探讨不同剂量131I对分化型甲状腺癌患者血清中甲状腺激素水平及生活质量的影响。方法：回顾性分析2012年1月―2015年3月我院收治的85例分化型甲状腺癌患者，所有患者均进行甲状腺癌切除手术，术后给予131I治疗，根据剂量不同分为3组，A组为1次应用131I治疗的患者，共27例，累计剂量为2.96～3.70 GBq，B组为2次应用131I治疗的患者，共23例，累计剂量为8.14～10.36 GBq，C组3次应用131I治疗的患者，共20例，累计剂量为12.95～17.02 GBq，比较3组患者治疗前后的临床疗效，生活质量评分，另15例同期未接受131I治疗的患者作为对照。结果： 131I治疗组的有效率均显著高于对照组，B、C组有效率最高，A组次之（P0.05）；3组患者治疗后躯体功能、角色功能、认知功能、情绪功能以及社会功能等方面的评分均显著高于治疗前， B组治疗后的生存质量评分最高，C组次之，A组最低，组间差异有统计学意义。结论：131I治疗分化型甲状腺癌疗效显著，可提高患者的生活质量，其中以B组的治疗方案效果最佳。 　　关键词 131I 分化型甲状腺癌 甲状腺激素 　　中图分类号：R736.1； R730.55 文献标识码：B 文章编号：1006-1533（2016）21-0036-04 　　Effects of the different doses of 131iodine on the serum thyroid hormone level and quality of life in the treatment of patients with differentiated thyroid cancer 　　WANG Yili1 XU Mingjun1 YANG Jing1 ZHONG Jinghua1 XIAO Lixia2 ZHONG Mingcao3（1. Department of Oncology， the First Hospital affiliated to Gannan Medical College， Ganzhou 341000， China；2. Department of Endocrinology， the First Hospital affiliated to Gannan Medical College， Ganzhou 341000， China；3. Isotope Laboratory， the First Hospital affiliated to Gannan Medical College， Ganzhou 341000， China） 　　ABSTRACT Objective： To discuss the different doses of 131I on serum thyroid hormone （TH） level and quality of life in the treatment of patients with differentiated thyroid cancer. Methods： Eighty-five patients with differentiated thyroid cancer were selected and underwent thyroid cancer resection surgery， and were postoperatively treated with 131I. They were divided into group A （27 cases， treated with a cumulative dose of 2.96 ～ 3.70 GBq once）， B （23 cases， treated with a cumulative dose of 8.14 ～ 10.36 GBq twice） and C （20 cases， treated with a cumulative dose of 12.95 ～ 17.02 GBq for three times）. Their clinical efficacy and the scores of the quality of life were compared before and after treatment. Meanwhile， another fifteen patients who did not received 131I treatment at the same time were selected as a control g