中药周期疗法对多囊卵巢综合征患者性激素和糖脂代谢影响.docVIP

中药周期疗法对多囊卵巢综合征患者性激素和糖脂代谢的影响 　　摘要：目的 观察中药周期疗法联合炔雌醇环丙孕酮片（达英-35）治疗多囊卵巢综合征（PCOS）临床疗效及其对性激素和糖脂代谢的影响。方法 将74例PCOS患者随机分为西药组和中西药组各37例，西药组予达英-35，中西药组在此基础上加用中药周期疗法，28 d为1个疗程，连续3个疗程。治疗前后及停药3个月观察2组临床症状、性激素和糖脂代谢变化。结果 2组各有2例失访。中西药组愈显率、总有效率优于西药组（P0.05）。治疗后中西药组各症状评分均下降（P0.01），2组血清雌二醇均升高（P0.01），黄体生成激素、睾酮和黄体生成激素/卵泡生成激素下降（P0.01）。治疗后、停药3个月中西药组临床症状、血清性激素水平改善优于西药组（P0.01），空腹血糖、空腹胰岛素、三酰甘油、总胆固醇和体质指数降低（P0.05），优于西药组（P0.05，P0.01）。西药组、中西药组不良反应发生率分别为17.1%和5.71%（P0.05）。结论 中药周期疗法联合达英-35治疗PCOS疗效显著，能明显改善患者临床症状，调节性激素和糖脂代谢紊乱状态，不良反应少。 　　关键词：多囊卵巢综合征；中药周期疗法；性激素；糖脂代谢 　　DOI：10.3969/j.issn.1005-5304.2016.01.008 　　中图分类号：R271.917.51 文献标识码：A 文章编号：1005-5304（2016）01-0035-04 　　Effects of TCM Periodic Therapy on Sex Hormone， Glucose and Lipid Metabolism of Patients with Polycystic Ovary Syndrome XU Bi-hong1， LI Mao-qing2， CHEN Chun-ling1， LUO Yu-ji1 （1. Wuyi TCM Hospital of Jiangmen， Jiangmen 529031， China； 2. FIMITIC Rehabilitation Hospital of Meizhou， Meizhou 514000， China） 　　Abstract： Objective To observe the clinical efficacy of TCM periodic therapy combined with estradiol progesterone tablets （Diane-35） in the treatment for polycystic ovary syndrome （PCOS）， and its effects on serum sex hormone， glucose and lipid metabolism. Methods Totally 74 patients with PCOS were randomly divided into Western medicine （WM） group and Chinese and Western medicine （CWM） group， 37 cases in each group. WM group was given Diane-35， while CWM group was treated with TCM periodic therapy additionally， for three courses， 28 d of one course. Clinical symptoms， sex hormones and glucose and lipid metabolism of two groups were observed before and after treatment and withdrawal treatment for 3 months. Results Two patients in each group were lost to follow-up. Markedly effective rate and total efficiency rate of CWM group were better than WM group （P 　　Key words： polycystic ovary syndrome； TCM periodic therapy； sex hormone； glucose and lipid metabolism 　　多囊卵巢综合征（polycystic ovarian syndromes， PCOS）是由于卵巢卵泡内膜细胞良性增生，引起雄激素分泌过多，造成月经紊乱或不