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J Infect Chemother (2012) 18:597–607 DOI 10.1007/s10156-012-0419-2 SURVEILLANCE Sensitivities of major causative organisms isolated from patients with acute uncomplicated cystitis against various antibacterial agents: results of subanalysis based on the presence of menopause Tetsuro Matsumoto • Ryoichi Hamasuna • Kiyohito Ishikawa • Satoshi Takahashi • Mitsuru Yasuda • Hiroshi Hayami • Kazushi Tanaka • Tetsuro Muratani • Koichi Monden • Soichi Arakawa • Shingo Yamamoto Received: 8 February 2012 / Accepted: 3 April 2012 / Published online: 11 May 2012 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2012 Abstract We investigated whether the presence of men- Major causative bacteria detected were Escherichia coli opause influenced the species and distribution of causative (65.0 %), Enterococcus faecalis (12.0 %), Streptococcus bacteria isolated from patients with acute uncomplicated agalactiae (5.5 %), and Klebsiella pneumoniae (1.6 %). cystitis (the most common urinary tract infection), and we From 501 postmenopausal patients (mean age 68.7 ± 10.29 also investigated the sensitivity of the isolated species to years), 657 strains were isolated, and the major causative antibacterial agents. Using multivariate analysis, we also bacteria detected were E. coli (61.5 %), E. faecalis investigated risk factors for infection with quinolone- (13.7 %), K. pneumoniae (5.2 %), and S. agalactiae resistant Escherichia coli, because its frequency has (4.0 %). The sensitivities to fluoroquinolones (FQs) and increased and it is now a clinical problem in Japan. Six cephems of E. coli isolated from premenopausal patients hundred and thirty-four strains were isolated from 489 were