体外循环对血小板影响及与术后急性肺损伤关系.docVIP

体外循环对血小板的影响及与术后急性肺损伤关系 　　[摘要] 目的：观察体外循环对血小板的影响及其与术后急性肺损伤关系。方法：回顾性总结分析采用体外循环手术方式的164例患者术前、术后血小板数目（PLT）、血小板平均容积（MPV）、血小板分布宽度(PDW)，比较手术前后各参数水平，并分析11例术后发生急性肺损伤患者的PLT、MPV、PDW与未发生急性肺损伤患者的差异。结果：体外循环术后的血小板计数[（106±61）×109/L]明显低于术前[（163±51）×109/L]，血小板平均容积[（11.21±3.06）fl]和血小板分布宽度[（18.61±2.01）%]高于术前水平[（8.21±2.01）fl、（15.21±1.64）%]，差异均有高度统计学意义（P0.01）。11例急性肺损伤患者的血小板计数[（90.36±20.61）×109/L]、血小板平均容积[（12.91±1.60）fl]、血小板分布宽度[（19.26±0.93）%]均差于未发生急性肺损伤患者[（107.36±51.20）×109/L、（11.09±2.66）fl、（17.76±1.81）%]，差异有统计学意义（P0.05）。结论：体外循环会降低患者血小板数目，增加血小板平均容积，增大血小板分布宽度。而且研究提示这与术后急性肺损伤有关。 　　[关键词] 体外循环；血小板；急性肺损伤 　　[中图分类号] R619 [文献标识码] Ａ [文章编号] 1673-7210（2011）11（b）-043-02 　　 　　Impact of cardiopulmonary bypass on platelet and relationship with postoperative acute lung injury 　　XIAO Qingwang 　　The Peoples Hospital in Luan County, Hebei Province, Luan County 063700, China 　　[Abstract] Objective: To observe the impact of cardiopulmonary bypass on platelet and relationship with postoperative acute lung injury. Methods: 164 cases of surgical operation patients platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) before and after the surgery were retrospectively analyzed. And 11 cases of acute lung injury patients postoperative platelet count, mean platelet volume, platelet distribution width were compared with non-acute lung injury patients. Results: The platelet count after cardiopulmonary bypass [(106±61)×109/L] was significantly lower than preoperative levels [(163±51)×109/L], mean platelet volume [(11.21±3.06)fl] and platelet distribution width [(18.61±2.01)%] was also higher than the level before surgery[(8.21±2.01)fl, (15.21±1.64)%], and there were significant differences between them (P0.01). 11 patients with acute lung injury in patients with platelet count [(90.36±20.61)×109/L], mean platelet volume [(12.91±1.60)fl], platelet distribution width [(19.26±0.93)%] conditions were worse than non-acute lung injury patients [(107.36±51.20)×109/L, (11.09±2.66)fl, (17.