低分子肝素与乙酰半胱氨酸联合治疗特发性间质性肺炎临床观察.docVIP

低分子肝素与乙酰半胱氨酸联合治疗特发性间质性肺炎的临床观察 　　【摘要】 目的 探?低分子肝素与乙酰半胱氨酸联合治疗对特发性间质性肺炎的临床效果。方法 68例特发性间质性肺炎患者， 按随机数字表法分为对照组与观察组， 各34例。对照组采用强的松联合环磷酰胺治疗， 观察组采用低分子肝素联合乙酰半胱氨酸治疗。观察两组患者的临床疗效。结果 观察组总有效率为91.18%， 高于对照组的70.59%， 差异有统计学意义（P0.05）。治疗后， 观察组患者血清Ⅲ型胶原水平为（62.37±9.25）ng/ml， 6 min步行试验距离（386.53±22.16）m， HRCT病变评分为（15.33±3.23）分， 对照组分别为（74.28±10.36）ng/ml、（321.65±21.28）m、（19.24±3.11）分， 治疗后观察组患者血清Ⅲ型胶原水平、6 min步行试验距离及HRCT评分等指标均优于对照组， 差异具有统计学意义（P0.05）。结论 低分子肝素联合乙酰半胱氨酸在特发性间质性肺炎患者治疗中的应用效果显著， 具有较高临床推广价值。 　　【关键词】 低分子肝素；乙酰半胱氨酸；特发性间质性肺炎 　　DOI：10.14163/j.cnki.11-5547/r.2017.09.047 　　Clinical observation of low molecular heparin and acetylcysteine in combined treatment of idiopathic interstitial pneumonia YIN Ming. Liaoning Linghai City Tuberculosis Prophylactico and Therapetic Institution， Linghai 121200， China 　　【Abstract】 Objective To investigate clinical effect by low molecular heparin and acetylcysteine in combined treatment of idiopathic interstitial pneumonia. Methods A total of 68 patients with idiopathic interstitial pneumonia were divided by random number table into control group and observation group， with 34 cases in each group. The control group received prednisone combined with cyclophosphamide for treatment， and the observation group received low molecular heparin combined with acetylcysteine for treatment. Observation was made on clinical effects between the two groups. Results The observation group had total effective rate as 91.18%， which was higher than 70.59% in the control group， and the difference had statistical significance （P0.05）. After treatment， the observation group had serum type Ⅲ collagen level as （62.37±9.25） ng/ml， 6 min walking distance as （386.53± 　　22.16） m and HRCT lesion score as （15.33±3.23） points， which were respectively （74.28±10.36） ng/ml， 　　（321.65±21.28） m and （19.24±3.11） points in the control group. After treatment the observation group had all better serum type Ⅲ collagen level， 6 min walking distance and HRCT lesion score than the control group， and