儿童肿瘤相关性早熟病因和临床特征分析.docVIP

儿童肿瘤相关性早熟病因和临床特征分析 　　【摘要】目的：探讨分析儿童肿瘤相关性早熟的病因及临床特征。方法：筛选2013年1月至2014年1月我院收治的肿瘤相关性早熟患儿40例作为研究对象。通过对其进行激素水平检测、乳房发育、睾丸容积、阴茎长度结合临床表现及治疗情况进行综合分析，总结儿童肿瘤相关性早熟的病因及临床特征。结果：本组实验结果表明性别对儿童肿瘤相关性早熟无影响，病因以下丘脑错构瘤较为多见，并且以外周性早熟为主要性早熟形式，其中男患儿以肾上腺皮质肿瘤、女患儿以卵巢囊肿致性早熟居多；临床特征分析中男患儿均以外生殖器发育，女患儿以乳房发育、阴道出血等为首发特征。结论：肿瘤是导致儿童性早熟的重要病因之一，而下丘脑错构瘤是导致儿童性早熟发生率最高的肿瘤类型，因此临床治疗应重视患儿的内分泌器官的发育及影响，同时也应注意少见肿瘤的诊断，综合诊断并及时采取预防、控制性早熟治疗方案。 　　【关键词】儿童肿瘤；性成熟；病因；临床特征 　　Etiological analysis of children with tumor-associated precocious puberty and its clinical characteristicsPANG Zhidong1， NING Dan2. 1. Pediatrics Department， NanningMaternal and Child Care Service Centre， Nanning 530011， China； 2. Obstetrics Department， NanningMaternal and Child Care Service Centre， Nanning 530011， China 　　【Abstract】Objectives： To investigate and analyze children with tumor-associated precocious puberty and its clinical characteristics. Methods： 40 children with tumor-associated precocious puberty in our hospital from January 2013 to January 2014 were selected as research subjects. Comprehensive analysis was conducted based on hormone level detection， breast development， testicular volume， penis length and their clinical manifestations and treatment status， to summarize the etiology and clinical characteristics of children with tumor-associated precocious puberty. Results： The experimental results showed that gender had no effect on tumor-associated precocious puberty， and hypothalamic hamartomas was the most common cause， with peripheral precocious puberty being the main form. The clinical characteristics of male patients were genital development， and for female children， breast development and vaginal bleeding were initial features. Conclusion： Tumor is one of the important causes leading to precocious puberty， and hypothalamic hamartoma is the most common type of tumor. Therefore， attention should be paid to the development of children’s endocrine organs， as well as the diagnosis of rare tumor， for comprehensive diagnosis and time