强化他汀治疗在急性冠脉综合征患者PCI术后中的应用效果观察.docVIP

强化他汀治疗在急性冠脉综合征患者PCI术后中的应用效果观察 　　[摘要] 目的 探讨急性冠脉综合征患者PCI术后应用强化他汀治疗的临床效果。 方法 选取本院2012年11月～2013年11月收治的88例急性冠脉综合征PCI术治疗的患者为研究对象，将其随机分成A组与B组，A组40例患者给予常规治疗，B组48例患者给予强化他汀治疗，观察两组患者的治疗效果。 结果 两组患者治疗后的胆固醇（TC）、低密度脂蛋白（LDL-C）、超敏C反应蛋白（hs-CRP）均较治疗前有所下降，B组下降更为明显，差异有统计学意义（P0.05）；治疗后两组患者的血浆丙氨酸氨基转移酶（ALT）、肌酐（Cr）均有所升高，但两组比较差异无统计学意义；A组患者心绞痛复发率为27.1%，心力衰竭发生率为18.7%，B组患者心绞痛复发率为15.0%，心力衰竭发生率为10.0%，B组患者的复发率及心力衰竭发生率明显低于A组，差异有统计学意义（P0.05）。 结论 急性冠脉综合征患者PCI术后应用大量他汀类药物进行强化治疗的临床效果较为显著，能显著改善患者的预后，值得在临床推广应用。 　　[关键词] 急性冠脉综合征；PCI术；强化治疗；他汀类药物 　　[中图分类号] R54 [文献标识码] A [文章编号] 1674-4721（2014）04（b）-0077-03 　　[Abstract] Objective To explore the clinical efficacy of applying statin intensive treatment to acute coronary syndrome （ACS） patients after PCI surgery. Methods Eighty-eight ACS patients who underwent PCI surgery admitted into our hospital from November 2012 to November 2013 were selected as research objects and randomly divided into group A and group B.In the group A （n=40），patients were treated by regular therapy，while in the group B （n=48），statin intensive treatment was provided.The efficacy in both groups were observed. Results After treatment，the total cholesterol （TC），low density lipoprotein cholesterol （LDL-C），and hypersensitive C reactive protein （hs-CRP） to some extent decreased in comparison with those before treatment in both groups.The decrease in the group B was more obvious with statistical differences （P0.05）.The alanine transaminase （ALT） and creatinine （Cr） after treatment both increased，but didn′t display a significant difference between the two groups.The recurrent rate of angina pectoris and incidence of cardiac failure in the group A were 27.1% and 18.7%，while in the group B，they were 15.0% and 10.0% in turn，which were much lower than those in the group A and displayed statistical differences （P0.05）. Conclusion Application of substantial amount of statins for intensive treatment in ACS patients after PCI surgery can obtain remarkable clinical effect and improve patient′s prognos