凝血四项在肝硬化诊断中应用及价值探析.docVIP

凝血四项在肝硬化诊断中应用及价值探析 　　[摘要] 目的 探讨凝血四项在肝硬化患者临床诊断中的应用及价值，为临床诊治肝硬化提供依据。 方法 选取2013年10月～2014年9月来我院就诊的96例肝硬化患者为研究组，以同期来我院体检的96例健康者为对照组，监测两组研究对象的凝血四项，即凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB），对两组的监测结果进行分析和比较。 结果 观察两组患者的PT、APTT、TT均长于对照组，差异有统计学意义（P0.05），且FIB含量少于对照组，差异有统计学意义（P0.05）。 结论 凝血四项可反映肝硬化患者的凝血功能状况，可作为诊断肝硬化患者的重要指标，通过检测患者的凝血四项，可以对其病情作出评估，从而为疾病的干预提供一定的参考。 　　[关键词] 凝血四项；诊断；肝硬化 　　[中图分类号] R445.1；R575.2 [文献标识码] B [文章编号] 2095-0616（2015）13-211-03 　　[Abstract] Objective To investigate the four items of blood coagulation in clinical diagnosis in patients with liver cirrhosis and application value， and provide the basis for clinical diagnosis and treatment of liver cirrhosis. Methods In 96 cases of liver cirrhosis from 2013 October to 2014 September method in our hospital for the study group， 96 cases in the same period health medical examination in our hospital as control group， monitoring of two groups of four blood coagulation indexes， including prothrombin time （PT）， activated partial thromboplastin time （APTT）， thrombin time （TT）， fibrinogen （FIB）， the monitoring results of the two groups were analyzed and compared. Results The two groups were observed in patients with PT， APTT， TT were significantly longer than the control group， the difference was statistically significant （P0.05）， and the FIB content was significantly less than that in the control group， the difference was statistically significant （P0.055）. Conclusion four items of blood coagulation can reflect the coagulation status in patients with liver cirrhosis， can be used as an important index for the diagnosis of patients with cirrhosis， through the detection of the four items of blood coagulation in patients and to evaluate its condition， in order to provide reference for the intervention of diseases. 　　[Key words] Four items of blood coagulation； Diagnosis； Liver cirrhosis 　　肝硬化（liver cirrhosis）主要病因是肝细胞变性、坏死、再生，同时广泛纤维组织增生，逐渐造成肝脏结构不可逆改变。早期可无明显症状，后期主要表现为肝功能损害和门脉高压，晚期常并发上消化道出血、肝性脑病、继发感染、脾功能亢进、腹水、癌变等疾病。