免疫细胞的免疫调节作用RegulatoryTCellsTreg-浙江大学.PPT

Th1,Th2,Th17 * Counter action of Th1 and Th2 subsets * IFN-? induced Th1 to activate intracellular killing Macrophages TB in Lysosomes * * 其他形式的免疫调节 * Regulation by apoptosis 1. Activation-induced cell death (AICD) * Regulation by neuroendocrine  system Lymphocytes express receptors for many hormones, neurotransmitters and neuropeptides. * * * Genetic control of immune response 1.Control of immune response by MHC Immune response genes (Ir) control all immune responses Most of the polymorphic residues in MHC molecules reside in the peptide-binding groove MHC restriction APC-Th, Th-B MHC II CTL-Target MHC I 2. Non-MHC-linked genes affect immune  response :TCR，BCR，C * Question The inhibitory receptors of immune system and its biological significance Difference between nature Treg and inducible Treg * * Figure 14.3. Anti-inflammatory effects of corticosteroid therapy. Corticosteroids regulate the expression of many genes, with a net anti-inflammatory effect. First, they reduce the production of inflammatory mediators, including cytokines, prostaglandins, and nitric oxide. Second, they inhibit inflammatory cell migration to sites of inflammation by inhibiting the expression of adhesion molecules. Third, corticosteroids promote the death by apoptosis of leukocytes and lymphocytes. Immunoregulation免疫调节 浙江大学免疫学研究所 陈建忠 chenjianzhong@zju.edu.cn * Immunoregulation Normal anti-infection anti-tumour Abnormal Auto-immune disease Tumour Persistent infection Allergy * Regulation of immunological milecules Immunoregulation mediated by immune cells Regulation by by other mechanism Immunoregulation 免疫分子的免疫调节作用 * Negative regulation of Ab production by Inhibitory receptor Fc?RII-B Interfere B cell signaling BCR (mIgM) 抗BCR抗体 Ag-Ab complex Fc?RII-B Fc?RII-B ITIM ITIM * Regulation by idiotypes and anti-idiotypic antibodies Antibodies formed against Ag-binding sites