去氧孕烯炔雌醇防治早期妊娠流产不全临床研究.docVIP

去氧孕烯炔雌醇防治早期妊娠流产不全临床研究 　　【摘要】目的：探究分析去氧孕烯炔雌醇预防与治疗早期妊娠流产不全患者的临床效果。方法：选取2010年3月至2013年5月来我院治疗的360例患者，随机分为实验组和对照组，每组患者180例。实验组患者服用去氧孕烯炔雌醇片剂，并且常规使用抗生素和促宫缩药；对照组患者只需常规使用抗生素和促宫缩药，探究实验组和对照组患者血清中内分泌物的变化；采用多普勒彩色超声检查实验组和对照组患者子宫内膜变化，分析GnRH、LH、FSH和E2与内分泌轴及子宫内膜的作用；通过比较实验组和对照组患者服用去氧孕烯炔雌醇前后的阴道出血量以及平均阴道出血时间，探究去氧孕烯炔雌醇治疗早期妊娠流产不全患者的临床效果。结果：实验组和对照组患者的FSH、LH、E2、PRE以及血HCG明显小于对照组患者，具有显著差异性（P005）；通过多普勒彩色超声检查看出实验组患者观察组子宫内膜明显修复较快，且宫腔明显缩小，具有统计学意义（P005）；实验组患者阴道出血量明显少于对照组，且平均出血时间小于对照组患者，有统计学意义。结论：通过观察实验组和对照组患者的血清内分泌物的变化、子宫内膜的变化、阴道出血量以及平均出血时间的变化，去氧孕烯炔雌醇片剂能够显著的预防和治疗早期妊娠流产不全疾病，明显提高临床治疗效果。 　　【关键词】去氧孕烯炔雌醇；早期妊娠流产不全；子宫内膜变化；阴道出血量；临床治疗效果 　　Clinical study of marvelon in the prevention and treatment of incomplete abortion in early pregnancyGONG Guixiang， DENG Xiucheng1， LIU Chunlei2. 1.Department of Pharmacy， Hefeng County Central Hospital， Enshi 445800， Hubei， China； 2. Department of Obstetrics and Gynecology， Enshi Central Hospital， Enshi 445000， Hubei， China 　　【Abstract】Objectives： To explore the clinical effects of marvelon in the prevention and treatment of patients with incomplete abortion in early pregnancy. Methods： 360 patients treated in our hospital from March 2010 to May 2013 were selected and randomly divided into experimental group and control group， with 180 patients in each group. Experimental group patients received marvelon tablet combined with routine use of antibiotics and drugs to promote uterine contractions； control patients simply received routine use of antibiotics and drugs to promote contractions. Endocrine changes in serum of experimental group and the control group was compared； Doppler Le color ultrasound examination was used to test endometrial changes of experimental group and control group patients and to analyze the connection between GnRH， LH， FSH and E2 and the endocrine axis and endometrium； vaginal bleeding and average vaginal bleeding time before and after the operation of experimental group and control group were compared to explore clinical outcomes of marvelon in