口腔鳞癌组织中IGF1表达及其临床意义.docVIP

口腔鳞癌组织中IGF1表达及其临床意义 　　doi：10.3969/j.issn.1007-614x.2014.18.73 　　摘要目的：探讨胰岛素样生长因子1（insulin-like growth factor 1，IGF-1）在口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）组织中的表达，并分析IGF-1的表达水平与口腔鳞癌患者各临床病理特征及其预后的关系。方法：采用免疫组织化学方法检测80例口腔鳞癌患者癌组织及20例正常口腔黏膜组织中IGF-1的表达。结果：①高、中、低分化口腔鳞癌IGF-1表达阳性率分别为44.1%、53.6%和72.2%（P0.05）；IGF-1表达与口腔鳞癌的病理分级呈正相关（rs=0.245）。②IGF-1表达阳性率在Ⅲ～Ⅳ期组、有颈部淋巴结转移组中分别明显高于Ⅰ～Ⅱ期组、无颈部淋巴结转移组（P0.05）。③IGF-1阴性表达的口腔鳞癌患者3年生存率（71.4%）明显高于阳性者的（29.0%）（P0.05）。结论：口腔鳞癌组织中IGF-1表达与肿瘤的分期、分化程度、淋巴结转移及预后有关。 　　关键词口腔鳞癌胰岛素样生长因子-1临床病理特征 　　Expression and clinical significance of IGF-1 in oral aquamous cell carcinoma 　　Lu Changlai，Xue Xiaoe 　　Department of Oncology，Nanjing Kang’ai Hospital，Jiangsu 210037 　　AbstractObjective：To investigate the expression of insulin-1ike growth factor 1（IGF-1） in oral squamous cell carcinoma（OSCC） tissues and analyze the clinicopathologic features and outcomes of OSCC on basis of IGF-1 expression.Methods： Immunohistochemical technique was used to detect the expression of IGF-1 in OSCC tissues（n=80） and normal tissues（n=20）. Results：①IGF-1 was positively expressed in cases of well differentiated（44.1%），moderately differentiated（53.6%） and poorly differentiated（72.2%）（P0.05），and it showed positive correlation with pathological grade of OSCC（r=0.245）.②The expression rate of IGF-1 in stageⅢ，Ⅳand cases with positive neck lymph node groups was significantly higher than that ofⅠ，Ⅱand those with negative neck lymph node（P0.05）.③The 3-year survival in OSCC patients with IGF-1 negative was significantly longer as compared with those with positive IGF-1（71.4% vs 29% ，P0.05）.Conclusion：IGF-1 expression level in OSCC tissues is associated with tumor stage and differentiation，involvement of lymph node metastasis and prognosis. 　　Key wordsOral squamous cell carcinoma；Insulin-1ike growth factor 1；Clinicopathologic feature 　　IGF-1是一种功能广泛的多肽因子，三维结构与胰岛素非常相似[1]。近些年来，国内外学者研究表明，IGF-1能在多种恶性肿瘤组织中表达，但是在不同肿瘤间，以及同种肿瘤在不同患者之间，IGF-1的异常表达都会存在一定程度上的差异[2，3]。本研究通过检测口腔鳞癌患者肿瘤组织IGF-1的表达情况，探讨其与口