参芪扶正注射液在恶性胸腔积液微波热疗联合化疗应用.docVIP

参芪扶正注射液在恶性胸腔积液微波热疗联合化疗应用 　　 [摘 要]目的 探讨参芪扶正注射液在恶性胸腔积液微波热疗联合化疗的应用。方法将60例患者分为对照组和治疗组。对照组行胸腔内热灌注化疗，治疗组加参芪扶正注射液，观察治疗期间的不良反应，治疗前、后T淋巴细胞亚群（CD3，CD4，CD8，CD4/CD8）的变化。结果 治疗组的不良反应少于对照组，有统计学差异（P0.05）。治疗组CD4/CD8提高，与对照组比较有显著性差异（P0.05）。结论应用参芪扶正注射液可明显改善免疫功能，帮助患者顺利完成治疗，提高患者生活质量。 　　关键词：恶性胸腔积液 参芪扶正注射液 化疗 　　Application of Shenqi Fuzheng injection（SQFZI）On microwave chemotherapy 　　JINCai-ling， MIAO Zhan-hui （Department of Medical Oncology，the First Affiliated Hospital of Xinxiang Medical College，Weihui 453100） 　　[Abstract] Objective To discuss the effect of Shenqi Fuzheng injection（SQFZI）On microwave chemotherapy for M alignant Pleural Effusion.Methods 60 cases with m alignant pleural effusion were randomly divided into two groups， control group received treatment of microwave chemotherapy and treated group received with Shenqi Fuzheng injection combined with microwave chemotherapy.We observed incidence rate of untoward reaction and detected the subsets of lymphocytes （CD3， CD4，CD8，CD4/CD8）in peripheral lymphocytes counts before and after treatment. 　　Results Incidence rate of untoward reaction in treated group were significantly lower than that in control group（P0.05）.There were statistical differences between two groups.The number of CD4/CD8 in treated group were significantly higher than that in control group. There was obvious difference of response between two groups（P0.05）.Conclusions SQFZl could effectively improve the immune function，help patient to finish their treatment，raise patients quality of life． 　　[Keywords] M alignant pleural effusion; Shenqi Fuzheng injection;chemotherapy; 　　中图分类号：R246.5 文献标识码：B 文章编号：1004-7484（2011）03-0005-03 　　 　　恶性胸腔积液是恶性肿瘤的并发症之一，全身化疗治疗恶性胸水效果不佳，胸腔化疗可缓解症状、改善预后。肿瘤患者免疫力低下加之化疗的影响，使患者无法完成全部的胸腔化疗。本研究应用参芪扶正注射液配合微波热疗联合化疗治疗恶性胸腔积液，观察其治疗效果，现将结果报告如下。 　　1 资料与方法 　　1.1 资料 　　我科自2009年8月至2010年9月收入60例恶性胸腔积液患者，均经病理学检查确诊，其中男28例，女32例；肺鳞癌28例，肺腺癌16例，小细胞未分化癌8例，乳腺癌5例；原发肿瘤部位不明者3例。Karnofsky评60分。随机分为对照组（胸腔化疗组）30例和治疗组（参芪扶正注射液加胸腔化疗）30例。两组在胸水量、病程、年龄、性别等方面差异无统计学意义。 　　1