参附注射液在感染性休克中应用价值.docVIP

参附注射液在感染性休克中应用价值 　　[摘要] 目的 探讨参附注射液在感染性休克中的应用价值。 方法 选取本院2011年12月～2013年12月治疗的感染性休克患者65例，将其随机分为对照组（30例）和实验组（35例），两组均给予常规治疗，包括纠正酸中毒、监护一般生命体征、控制原发病、治疗感染、预防并发症、扩充血容量、多巴胺升压等，实验组在常规治疗的基础上加用参附注射液进行治疗。比较两组的临床疗效。 结果 实验组总有效率为68.57％，高于对照组的40.00％，差异有统计学意义（P0.05）。实验组血压恢复正常的时间为（18±7） min，对照组血压恢复正常的时间为（30±6） min，两组差异有统计学意义（P＜0.05）。 结论 参附注射液能明显增加治疗感染性休克的疗效，缩短血压恢复正常的时间，具有良好的应用前景。 　　[关键词] 参附注射液；感染性休克；应用价值 　　[中图分类号] R972+.5[文献标识码] A[文章编号] 1674-4721（2014）04（c）-0081-03 　　 　　Application value of Shenfu injection in the treatment of septic shock 　　LI Ying ZHENG Xiao-bin CHEN Ting 　　The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China 　　[Abstract] Objective To analyze the application value of Shenfu injection in the treatment of septic shock.Methods 65 cases of patients with septic shock in our hospital from December 2011 to December 2013 were selected,and were randomly divided into control group (30 cases) and experimental group (35 cases).Both two groups were given conventional treatment,such as correct acidosis,monitoring of vital signs,the general control of the primary disease,treatment,prevention of infection complications,expansion of blood volume,dopamine booster etc.,while the experimental group was treated with Shenfu injection on the basis of conventional therapy.Results The total effective rate of experimental group was 68.57％,higher than 40.00％ of the control group,the difference was significant (P0.05).The time of blood pressure returned to normal in experimental group was (18±7) min,was shorter than (30±6) min of the control group,the difference was significant (P0.05).Conclusion Shenfu injection can be used to the disease of septic shock and reduce the time of blood pressure returned to normal,it has a good prospect for application. 　　[Key words] Shenfu injection;Septic shock;Application value 　　参附注射液是从红参和黑附子中提取的，是由中医治疗休克的著名的参附汤制成的中药注射剂，具有温阳益气的功效，现代药理学已证明了其具有多种药学作用[1-5]。参附注射液中含有人参皂苷和乌头类生物碱，两者为其主要活性成分。人参皂苷类似于强心苷，具有强心作用。乌头类生物碱的去甲乌头碱为β-受体激动剂，