参麦注射液对非小细胞肺癌患者术后辅助化疗期间免疫功能影响.docVIP

参麦注射液对非小细胞肺癌患者术后辅助化疗期间免疫功能影响 　　[摘要] 目的 观察参麦注射液对非小细胞肺癌患者术后辅助化疗期间免疫功能的影响。 方法 将60例行术后辅助化疗的非小细胞肺癌患者随机分为试验组和对照组，每组各30例，对照组采用GP方案化疗，试验组在对照组基础上加用参麦注射液，分别于4次化疗前后，对两组患者的淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+、CD19+、NK）指标及免疫球蛋白（IgA、IgG、IgM）水平进行比较。 结果 化疗后试验组的CD3+、CD4+、CD4+/CD8+、CD19+、NK、IgA、IgG、IgM均显著高于对照组，CD8+显著低于对照组，两组差异有统计学意义（P0.05）。 结论 参麦注射液可显著提高非小细胞肺癌患者术后辅助化疗期间的免疫功能。 　　[关键词] 参麦注射液；非小细胞肺癌；辅助化疗；免疫功能 　　[中图分类号] R734.2 [文献标识码] B [文章编号] 1673-9701（2018）07-0079-03 　　[Abstract] Objective To observe the effect of Shenmai injection on immune function in patients with non-small cell lung cancer during adjuvant chemotherapy after surgery. Methods 60 patients with postoperative adjuvant chemotherapy for non-small cell lung cancer were randomly divided into experimental group and control group， with 30 cases in each group. The control group was treated with GP regimen. The experimental group was treated with Shenmai injection on the basis of the treatment in the control group. The levels of lymphocyte subsets（CD3+， CD4+， CD8+， CD4+/CD8+， CD19+， NK） and immunoglobulins（IgA， IgG， IgM） were compared between the two groups before and after four times of chemotherapy. Results After chemotherapy， the levels of CD3+， CD4+， CD4+/CD8+， CD19+， NK， IgA， IgG and IgM in the experimental group were significantly higher than those in the control group， and the CD8+ was significantly lower than that in the control group（P0.05）. There was significant difference between the two groups（P0.05）. Conclusion Shenmai injection can significantly improve the immune function of patients with non-small cell lung cancer during adjuvant chemotherapy after surgery. 　　[Key words] Shenmai injection； Non-small cell lung cancer； Adjuvant chemotherapy； Immune function 　　参麦注射液源于《千金要方》之生脉散，具有益气养阴的功效，可显著加强机体免疫功能，对化疗有一定的增效减毒功能。免疫功能在恶性肿瘤患者的治疗过程中起着至关重要的作用，若患者的免疫功能低下，会严重影响治疗效果并进一步影响预后。本研究将2016年1～12月期间湖州市第一人民医院胸外科收治的60例非小细胞肺癌术后辅助化疗患者随机分为试验组和对照组，分别于4次化疗前后，对两组患者的淋巴细胞亚群指标及免疫球蛋白水平进行比较，以观察参麦注射液对非小细胞肺癌患者术后辅助化疗期间免疫功能的影响，现报道如下。 　　1资料与方法