基于共引分析艾滋病疫苗技术前沿研究.docVIP

基于共引分析艾滋病疫苗技术前沿研究 　　[摘要] 目的 探讨艾滋病疫苗技术的研究现状及其发展态势。 方法 以艾滋病疫苗为主题在Web of science数据库中检索研究论文，用TDA软件进行数据清洗和处理，采用共引分析方法，借助Ucinet和SPSS?稻莘治龉ぞ撸?从论文的国家/地区分布、国家/地区合作网络和被引文献等计量指标入手进行统计分析。 结果 研究发现2011年以来艾滋病疫苗技术领域论文主要集中在美国、英国等国家，其中中国论文数量排在第4位；中国在艾滋病疫苗技术领域国际合作较少；通过研究得出HIV-1可溶性膜蛋白三聚体结构研究、HIV/AIDS动物模型研究等9个艾滋病疫苗技术的前沿领域。 结论 近年来国际上艾滋病疫苗技术研究领域发展迅速，但我国的研究实力相对美国等发达国家仍比较薄弱。 　　[关键词] 艾滋病疫苗；文献计量；共引分析；信息可视化 　　[中图分类号] R512.91；G257 [文献标识码] A [文章编号] 1673-7210（2017）02（b）-0169-04 　　[Abstract] Objective To discuss the research situation and development trend of AIDS vaccine technology. Methods The research papers about the theme of AIDS vaccine technology from the Web of science database were retrieved， the data was cleaned and managed by TDA software. The development trend from the country/region distribution， country/region cooperation network， cited literature and other aspects were made statistical analysis by the method of co-citation analysis and visual tools such as Ucinet and SPSS. Results The research found that AIDS vaccine technology in the field of papers has been mainly concentrated in the United States， Britain and other countries since 2011， of which， the number of Chinese papers ranked fourth. The international cooperation in the AIDS vaccine field of China was less. There were 9 frontier fields of AIDS vaccine technologies through the research such as structure of a soluble cleaved HIV-1 envelope trimer， the research on animal model of HIV/AIDS. Conclusion In recent years， the research of AIDS vaccine technology has developed rapidly in the world， but the research strength of our country is still relatively weak compared with developed countries such as the United states. 　　[Key words] AIDS vaccine； Bibliometric analysis； Co-citation analysis； Information visualization 　　艾滋病，全称为获得性免疫缺陷综合征（acquired immune deficiency syndrome），是由感染艾滋病病毒（HIV）引起，进而损害人体免疫系统，导致患者丧失免疫功能，甚至死亡的传染性疾病[1]，并已经成为各个国家不容忽视的疾病[2-3]，由此带来的社会问题也日益凸现。尽管艾滋病新药不断涌现，但由于HIV本身高度的变异性和快速的耐药性，始终为医学上的难题。因此，研制出安全有效的艾滋病疫苗毫无疑问