多索茶碱联合布地奈德治疗支气管哮喘临床疗效观察.docVIP

多索茶碱联合布地奈德治疗支气管哮喘临床疗效观察 　　[摘要] 目的 探讨多索茶碱联合布地奈德治疗支气管哮喘的临床疗效。 方法 回顾性分析2012年12月～2014年12月我院接诊的支气管哮喘住院患者102例临床资料，根据治疗方法将所有患者分为两组，其中50例患者给予雾化布地奈德作为对照组，观察组为52例采用多索茶碱联合布地奈德治疗的患者。对比两组患者的治疗效果、FEV1、FVC、PEF及不良反应发生情况。 结果 两组患者采用不同治疗方法治疗后，观察组总有效率为94.23%明显高于对照组总有效率82.00%，差异有统计学意义（x2=5.096，P0.05），治疗后两组患者肺功能及PaO2、PaCO2均有明显改善，差异有统计学意义（P0.05），且观察组FEV1/FVC及PaO2、PaCO2均明显优于对照组，差异有统计学意义（P0.05）。治疗后，观察组患者不良反应发生率为13.47%，明显少于对照组患者不良反应发生率34.00%，差异有统计学意义（x2=6.526，P0.05）。 结论 多索茶碱联合布地奈德治疗支气管哮喘能够改善患者的呼吸功能，效果显著，安全性高。 　　[关键词] 多索茶碱；布地奈德；支气管哮喘；氨茶碱 　　[中图分类号] R562.25 [文献标识码] B [文章编号] 2095-0616（2015）17- 　　The clinical curative effect of doxofylline combined with budesonide for bronchial asthma 　　LIU Jian GONG Ying 　　Department of Pharmacy，the Fourth Peoples Hospital of Jinan City， Jinan 250031，China 　　[Abstract] Objective To investigate the clinical curative effect of doxofylline combined with budesonide for bronchial asthma. Methods The clinical data of 102 patients with bronchial asthma were retrospectively analyzed，who were in hospital from December 2012 to December 2014，and divided into two groups according to the treatment method.50 patients were given budesonide as control group，and observation group of 52 cases were treated with doxofylline combined with budesonide. Results After different treatment methods of two groups，the total effective rate of observation group was 94.23%，significantly higher than that of the control group 82.00%.The difference was statistically significant（x2=5.096，P0.05）.After treatment，pulmonary function and PaO2，PaCO2 of two groups were significantly improved（P0.05），and the observation group FEV1/FVC， PaCO2 and PaO2 were significantly better than that of the control group，the difference was statistically significant （P0.05）.The adverse reaction rate of observation group was 13.47%，significantly less than that of the control group of 34.00%，with the statistical significance differences（x2=6.526，P0.05）. Conclusion Doxofylline combined with budesonide in the treatment