复方马蹄香治疗广泛性焦虑症临床研究.docVIP

复方马蹄香治疗广泛性焦虑症临床研究 　　[摘要] ?^察复方马蹄香对肝气郁结、心神不宁型广泛性焦虑患者的临床疗效。选择67例属肝气郁结、心神不宁型的广泛性焦虑症患者，随机分为治疗组（34例）和对照组（33例），治疗组给予复方马蹄香，对照组给予黛力新治疗，2组均采用药物治疗4周。治疗前及治疗第2，4周采用汉密尔顿焦虑量表（HAMA）进行疗效评价；以中医证候量表（肝气郁结、心神不宁型）观察焦虑评分；同时取患者唾液测定皮质醇（cortisol）含量；并于治疗前和治疗4周后测量生活事件量表（LES），进行药物安全性评价。通过测量生活事件量表剔除2例患者，中止5例，最终共60例患者纳入该研究（每组30例）。2组患者HAMA总分在治疗第2，4周时均有所改善（P0.05，P0.01）；中医证候量表积分改善情况在治疗2，4周后均具有显著统计学意义（P0.01）；唾液皮质醇水平在治疗第2，4周时均有所下降（P0.05，P0.01）。治疗2周后与4周后2组间比较总有效率无统计学意义差异，HAMA积分、中医证候量表积分、唾液皮质醇水平改善方面组间差异也均无统计学差异。不良反应发生率方面，治疗组（6.67%）低于对照组（13.3%）（P0.01），受试者治疗期间一般体检项目未见明显异常。因此，复方马蹄香对肝气郁结、心神不宁型广泛性焦虑症疗效确切。 　　[关键词] 复方马蹄香； 广泛性焦虑； 肝气郁结； 心神不宁； 临床研究 　　[Abstract] This study was aimed to observe the clinical efficacy of anxiolytic compound prescription with Valerianae Jatamansi Rhizoma et Radix （ACPV） in treating liver Qi stagnation and feel ill at ease type generalized anxiety disorder （GAD）. Sixty-seven patients diagnosed as GAD with stagnation of liver Qi and feel ill at ease were randomly divided into treatment group and control group. Patients in treatment group （n=34） was treated with ACPV decoction， and patients in control group （n=33） were treated with deanxit. Both groups were treated with respective drugs for 4 weeks. HAMA scale， traditional Chinese medicine （TCM） symptom scale （liver Qi stagnation and feel ill at ease type） and salivary cortisol levels were measured before and 2 weeks and 4 weeks after drug treatment. The life events scale （LES） and drug safety evaluation were performed before and after 4 weeks treatment. Two patients were excluded according to LES， and 5 patients were discontinued. Sixty patients were enrolled in the study finally （30 cases in each group）. As compared with baseline， HAMA scores in both groups were significantly decreased at 2 weeks and 4 weeks （P 　　[Key words] compound prescription with Valerianae Jatamansi Rhizoma et Radix； generalized anxiety disorder； stagnation of liver Qi； feel ill at ease； clinical research 　　广泛性焦虑（又称慢性焦虑，generalized anxiety disorder，GAD）是焦虑