11秋C15 免疫耐受幻灯片.pptVIP

* 思 考 题 免疫耐受的定义及特点及分类。 免疫耐受的机制有哪些？ 低带/高带耐受、T/B细胞耐受的特点？ * * Need for tissue and organ graft drove the curiosity to understand the mechanisms of tolerance. The observations a zoologist, Owens, that Dizygotic bovine twins could accept grafts from each other but their siblings from other pregnancies could not tolerate such grafts led Medawar to perform a series of experiments to induce tolerance in mice. * * * * Clonal deletion: Functionally immature cells of a clone encountering antigen undergo a programmed cell death. For example, auto-reactive T-cell are eliminated in the thymus following in